Q6GDD3 (LIP1_STAAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 1
EC=3.1.1.3

Alternative name(s):
Glycerol ester hydrolase 1

Gene names

Name:	lip1
Ordered Locus Names:	SAR2753

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.
Sequence caution	The sequence CAG41728.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Propeptide	35 – 290	256	By similarity		PRO_0000045180
	Chain	291 – 680	390	Lipase 1		PRO_0000045181
Sites
	Active site	408	1	Charge relay system By similarity
	Active site	639	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GDD3 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 4D7AB17A5A15384A	FASTA	680	76,601
	10 20 30 40 50 60 MKSQNKYSIR KFSVGASSIL IATLLFLSGG QAQAAEKQVN MGNSQEDTVT AQSIGDQQTR 70 80 90 100 110 120 ENANYQRENG VDEQQHTENL TKNLHNDKTI SEENHRKTDD LNKDQLKDDK KSSLNNKNIQ 130 140 150 160 170 180 RDTTKNNNAN PRDVNQGLEQ AINDGKQSKV ASQQQSKEAD NSQDLNANNN LPSQSRTKVS 190 200 210 220 230 240 PSLNKSDQTS QREIVNETEI EKVQPQQKNQ ANDKITDHNF NNEQEVKPQK DEKTLSVSDL 250 260 270 280 290 300 KNNQKSPVEP TKDNDKKNGL NLLKSSAVAT LPNKGTKELT AKAKGDQTNK VAKQGQYKNQ 310 320 330 340 350 360 DPIVLVHGFN GFTDDINPSV LAHYWGGNKM NIRQDLEENG YKAYEASISA FGSNYDRAVE 370 380 390 400 410 420 LYYYIKGGRV DYGAAHAAKY GHERYGKTYE GIYKDWKPGQ KVHLVGHSMG GQTIRQLEEL 430 440 450 460 470 480 LRNGSREEIE YQKKHSGEIS PLFKGNNDNM ISSITTLGTP HNGTHASDLA GNEALVRQIV 490 500 510 520 530 540 FDIGKMFGNK NSRVDFGLAQ WGLKQKPNES YIDYVKRVKQ SNLWKSKDNG FYDLTREGAT 550 560 570 580 590 600 DLNRKTSLNP NIVYKTYTGE ATHKALNSDR QKADLNMFFP FVITGNLIGK ATEKEWREND 610 620 630 640 650 660 GLVSVISSQH PFNQAYTNAT DKIQKGIWQV TPTKHDWDHV DFVGQDSSDT VRTREELQDF 670 680 WHHLADDLVK TEKVTDTKQA

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MRSA252.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG41728.1. Different initiation.
RefSeq	YP_042090.1. NC_002952.2.
3D structure databases
ProteinModelPortal	Q6GDD3.
SMR	Q6GDD3. Positions 297-677.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GDD3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000019927; EBSTAP00000019263; EBSTAG00000019926.
GeneID	2859804.
GenomeReviews	Gene locus SAR2753 in contig BX571856_GR.
KEGG	sar:SAR2753.
PATRIC	19549220. VBIStaAur71814_2788.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1075.
GeneTree	EBGT00050000023709.
HOGENOM	HBG694146.
OMA	YTGESTH.
ProtClustDB	CLSK2752181.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR2753-MONOMER.
Family and domain databases
InterPro	IPR005877. Gpos_YSIRK. [Graphical view]
KO	K01046.
Pfam	PF04650. YSIRK_signal. 1 hit. [Graphical view]
TIGRFAMs	TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP1_STAAR

Accession

Primary (citable) accession number: Q6GDD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program