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Q6GDC6

- HISX_STAAR

UniProt

Q6GDC6 - HISX_STAAR

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191NADUniRule annotation
Binding sitei180 – 1801NADUniRule annotation
Binding sitei203 – 2031NADUniRule annotation
Binding sitei226 – 2261SubstrateUniRule annotation
Metal bindingi248 – 2481ZincUniRule annotation
Binding sitei248 – 2481SubstrateUniRule annotation
Metal bindingi251 – 2511ZincUniRule annotation
Binding sitei251 – 2511SubstrateUniRule annotation
Active sitei316 – 3161Proton acceptorUniRule annotation
Active sitei317 – 3171Proton acceptorUniRule annotation
Binding sitei317 – 3171SubstrateUniRule annotation
Metal bindingi350 – 3501ZincUniRule annotation
Binding sitei350 – 3501SubstrateUniRule annotation
Binding sitei404 – 4041SubstrateUniRule annotation
Metal bindingi409 – 4091ZincUniRule annotation
Binding sitei409 – 4091SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2798-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:SAR2760
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Histidinol dehydrogenasePRO_0000135850Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi282458.SAR2760.

Structurei

3D structure databases

ProteinModelPortaliQ6GDC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GDC6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMLNAQQFL NQFSLEAPLD ESLYPIIRDI CQEVKVHGDK ALKMYNLTFD
60 70 80 90 100
HTKTDHLEIS HEQIKAAFDT LDEKTKQALQ QSYERIKAYQ ESIKQMNQQL
110 120 130 140 150
EESVECYEIY HPLESVGIYV PGGKASYPST VLMTATLAQV AGVENIVVVT
160 170 180 190 200
PPQPNGVSQE VLAACYITQV NQVFQVGGAQ SIAALTYGTE TIPKVDKIVG
210 220 230 240 250
PGNQFVAYAK KYLFGQVGID QIAGPTEIAL IIDDTADLDA IVYDVFAQAE
260 270 280 290 300
HDELARTYVI SEDAQVLKDL ESRIAKALPN VDRYDIVSKS IANQHYLIHA
310 320 330 340 350
SNFDEACHVM NTIAPEHASI QTVNPQPYIE KVKYVGALFI GHYSPEVIGD
360 370 380 390 400
YVAGPSHVLP TNRTARFTNG LSVNDFLTRN TVIHLSKDTF DQIADSAQHI
410
AHVEALYNHQ QSILIRQS
Length:418
Mass (Da):46,435
Last modified:July 19, 2004 - v1
Checksum:i519DCD4181C2EB61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41735.1.
RefSeqiYP_042097.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41735; CAG41735; SAR2760.
GeneIDi2860710.
KEGGisar:SAR2760.
PATRICi19549236. VBIStaAur71814_2796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41735.1 .
RefSeqi YP_042097.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GDC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR2760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG41735 ; CAG41735 ; SAR2760 .
GeneIDi 2860710.
KEGGi sar:SAR2760.
PATRICi 19549236. VBIStaAur71814_2796.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SAUR282458:GJA5-2798-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiHISX_STAAR
AccessioniPrimary (citable) accession number: Q6GDC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3