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Protein

DNA polymerase III subunit beta

Gene

dnaN

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit beta (EC:2.7.7.7)
Gene namesi
Name:dnaN
Ordered Locus Names:SAS0002
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377DNA polymerase III subunit betaPRO_0000105466Add
BLAST

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GD88.
SMRiQ6GD88. Positions 2-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000071792.
KOiK02338.
OMAiTHQIRLK.

Family and domain databases

CDDicd00140. beta_clamp. 1 hit.
InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GD88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEFTIKRDY FITQLNDTLK AISPRTTLPI LTGIKIDAKE HEVILTGSDS
60 70 80 90 100
EISIEITIPK TVDGEDIVNI SETGSVVLPG RFFVDIIKKL PGKDVKLSTN
110 120 130 140 150
EQFQTLITSG HSEFNLSGLD PDQYPLLPQV SRDDAIQLSV KVLKNVIAQT
160 170 180 190 200
NFAVSTSETR PVLTGVNWLI QENELICTAT DSHRLAVRKL QLEDVSENKN
210 220 230 240 250
VIIPGKALAE LNKIMSDNEE DIDIFFASNQ VLFKVGNVNF ISRLLEGHYP
260 270 280 290 300
DTTRLFPENY EIKLSIDNGE FYHAIDRASL LAREGGNNVI KLSTGDDVVE
310 320 330 340 350
LSSTSPEIGT VKEEVDANDV EGGSLKISFN SKYMMDALKA IDNDEVEVEF
360 370
FGTMKPFILK PKGDDSVTQL ILPIRTY
Length:377
Mass (Da):41,914
Last modified:July 19, 2004 - v1
Checksum:i0A985EF94E044FBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG41774.1.
RefSeqiWP_000969811.1. NC_002953.3.

Genome annotation databases

KEGGisas:SAS0002.
PATRICi19549323. VBIStaAur96780_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG41774.1.
RefSeqiWP_000969811.1. NC_002953.3.

3D structure databases

ProteinModelPortaliQ6GD88.
SMRiQ6GD88. Positions 2-377.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisas:SAS0002.
PATRICi19549323. VBIStaAur96780_0002.

Phylogenomic databases

HOGENOMiHOG000071792.
KOiK02338.
OMAiTHQIRLK.

Family and domain databases

CDDicd00140. beta_clamp. 1 hit.
InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPO3B_STAAS
AccessioniPrimary (citable) accession number: Q6GD88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.