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Q6GCT1

- HSDR_STAAS

UniProt

Q6GCT1 - HSDR_STAAS

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Protein
Type-1 restriction enzyme R protein
Gene
hsdR, SAS0170
Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunit R is required for both nuclease and ATPase activities, but not for modification By similarity.

Catalytic activityi

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2747ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Protein family/group databases

REBASEi9413. SauMSSORF170P.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 restriction enzyme R protein (EC:3.1.21.3)
Alternative name(s):
Type I restriction enzyme R protein
Gene namesi
Name:hsdR
Ordered Locus Names:SAS0170
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002201: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 929929Type-1 restriction enzyme R protein
PRO_0000077269Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Protein-protein interaction databases

STRINGi282459.SAS0170.

Structurei

3D structure databases

ProteinModelPortaliQ6GCT1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini254 – 418165Helicase ATP-binding
Add
BLAST

Sequence similaritiesi

Belongs to the HsdR family.

Phylogenomic databases

eggNOGiCOG0610.
HOGENOMiHOG000003518.
KOiK01153.
OMAiNNGYIWH.
OrthoDBiEOG6JTCB4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
IPR022625. TypeI_RM_Rsu_C.
[Graphical view]
PfamiPF12008. EcoR124_C. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00348. hsdR. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GCT1-1 [UniParc]FASTAAdd to Basket

« Hide

MAYQSEYALE NEMMNQLEQL GYERVTIRDN KQLLDNFRTI LNERHADKLE    50
GNPLTDKEFQ RLLTMIDGKS IFESARILRD KLPLRRDDES EVYLSFLDTK 100
SWCKNKFQVT NQVSVEDTYK ARYDVTILIN GLPLVQVELK RRGIDINEAF 150
NQVKRYRKQN YTGLFRYIQM FIISNGVETR YFSNNDSELL KSHMFYWSDK 200
QNNRINTLQS FAESFMRPCQ LAKMISRYMI INETDRILMA MRPYQVYAVE 250
ALIQQATETG NNGYVWHTTG SGKTLTSFKA SQILSQQDDI KKVIFLVDRK 300
DLDSQTEEEF NKFAKGAVDK TFNTSQLVRQ LNDKSLPLIV TTIQKMAKAI 350
QGNAHLLEQY KTNKVVFIID ECHRSQFGDM HRLVKQHFKN AQYFGFTGTP 400
RFPENSSQDG RTTADIFGRC LHTYLIRDAI HDGNVLGFSV DYINTFKNKA 450
LKAEDNSMVE AIDTEEVWLA DKRVELVTRH IINNHDKYTR NRQYSSIFTV 500
QSIHALIKYY ETFKRLNKKL EQPLTIAGIF TFKPNEDDRD GEVPYHSREK 550
LEIMISDYNK KFETNFSTDT TNEYFNHISK NVKKGVKDSK IDILIVVNMF 600
LTGFDSKVLN TLYVDKNLMY HDLIQAYSRT NRVEKESKPF GKIVNYRDLK 650
KETDDALRVF SQTNDTDTIL MRSYEEYKKE FMDAYRELKM IVPTPHMVDD 700
IQDEEELKRF VEAYRLLAKI ILRLKAFDEF EFTIDEIGMD EQENEDYKSK 750
YLAVYDQVKR ATAEKNKVSI LNDIDFEIEM MRNDTINVNY IMNILRQIDL 800
EDKAEQRRNQ EQIRRILDHA DDPTLRLKRD LIREFIDNVV PSLNKDDDID 850
QEYVNFESIK KEAEFKGFAG ERSIDEQALK TISNDYQYSG VVNPHHLKKM 900
IGDLPLKEKR KARKAIESFV AETTEKYGV 929
Length:929
Mass (Da):109,253
Last modified:July 19, 2004 - v1
Checksum:i1F8E22880C217804
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571857 Genomic DNA. Translation: CAG41938.1.
RefSeqiYP_042292.1. NC_002953.3.

Genome annotation databases

GeneIDi2862691.
KEGGisas:SAS0170.
PATRICi19549686. VBIStaAur96780_0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571857 Genomic DNA. Translation: CAG41938.1 .
RefSeqi YP_042292.1. NC_002953.3.

3D structure databases

ProteinModelPortali Q6GCT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282459.SAS0170.

Protein family/group databases

REBASEi 9413. SauMSSORF170P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2862691.
KEGGi sas:SAS0170.
PATRICi 19549686. VBIStaAur96780_0181.

Phylogenomic databases

eggNOGi COG0610.
HOGENOMi HOG000003518.
KOi K01153.
OMAi NNGYIWH.
OrthoDBi EOG6JTCB4.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
IPR022625. TypeI_RM_Rsu_C.
[Graphical view ]
Pfami PF12008. EcoR124_C. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00348. hsdR. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSSA476.

Entry informationi

Entry nameiHSDR_STAAS
AccessioniPrimary (citable) accession number: Q6GCT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and magnesium as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi