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Protein

Ribitol-5-phosphate cytidylyltransferase 2

Gene

tarI2

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.UniRule annotation

Catalytic activityi

CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol.UniRule annotation

Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei14Transition state stabilizerUniRule annotation1
Sitei22Transition state stabilizerUniRule annotation1
Binding sitei112CTPUniRule annotation1
Sitei160Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1
Sitei217Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 10CTPUniRule annotation4
Nucleotide bindingi81 – 87CTPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Teichoic acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00790.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribitol-5-phosphate cytidylyltransferase 2UniRule annotation (EC:2.7.7.40UniRule annotation)
Gene namesi
Name:tarI2UniRule annotation
Ordered Locus Names:SAS0227
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000756211 – 238Ribitol-5-phosphate cytidylyltransferase 2Add BLAST238

Structurei

3D structure databases

ProteinModelPortaliQ6GCM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218563.
KOiK00991.
OMAiGACDTVI.

Family and domain databases

CDDicd02516. CDP-ME_synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02068. TarI. 1 hit.
InterProiIPR001228. IspD.
IPR018294. ISPD_synthase_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01128. IspD. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS01295. ISPD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GCM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYAGILAGG IGSRMGNVPL PKQFLDIDNK PILIHTIEKF ILVSEFNEII
60 70 80 90 100
IATPAQWISH TQDILKKYNI TDQRVKVVAG GTDRNETIMN IIDYIRNVNG
110 120 130 140 150
INNDDVIVTH DAVRPFLTQR IIKENIEVAE KYGAVDTVIE AIDTIVMSKD
160 170 180 190 200
KQNIHSIPVR NEMYQGQTPQ SFNIKLLQDS YRALSSAQKE ILSDACKIIV
210 220 230
ESGHPVKLVR GELYNIKVTT PYDLKVANAI IQGDIADD
Length:238
Mass (Da):26,627
Last modified:July 19, 2004 - v1
Checksum:iF21440DA33D18AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG41996.1.
RefSeqiWP_000638479.1. NC_002953.3.

Genome annotation databases

KEGGisas:SAS0227.
PATRICi19549802. VBIStaAur96780_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG41996.1.
RefSeqiWP_000638479.1. NC_002953.3.

3D structure databases

ProteinModelPortaliQ6GCM3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisas:SAS0227.
PATRICi19549802. VBIStaAur96780_0239.

Phylogenomic databases

HOGENOMiHOG000218563.
KOiK00991.
OMAiGACDTVI.

Enzyme and pathway databases

UniPathwayiUPA00790.

Family and domain databases

CDDicd02516. CDP-ME_synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02068. TarI. 1 hit.
InterProiIPR001228. IspD.
IPR018294. ISPD_synthase_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01128. IspD. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTARI2_STAAS
AccessioniPrimary (citable) accession number: Q6GCM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.