Q6GBX4DHPS_STAASDihydropteroate synthaseDHPS2.5.1.15Dihydropteroate pyrophosphorylasefolPSAS0471Staphylococcus aureus (strain MSSA476)BacteriaBacillotaBacilliBacillalesStaphylococcaceaeStaphylococcusComplete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphateMg(2+)Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.Homodimer.Belongs to the DHPS family.Folate biosynthesisMagnesiumMetal-bindingTransferaseMg(2+)(7,8-dihydropterin-6-yl)methyl diphosphate(7,8-dihydropterin-6-yl)methyl diphosphate(7,8-dihydropterin-6-yl)methyl diphosphate(7,8-dihydropterin-6-yl)methyl diphosphate(7,8-dihydropterin-6-yl)methyl diphosphate(7,8-dihydropterin-6-yl)methyl diphosphateMTKTKIMGILNVTPDSFSDGGKFNNVESAINRVKAMIDEGVDIIDVGGVSTRPGHEMVSLEEEMNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDMINDQWAGLYDHRMFQIVAKYDAEIILMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGIPSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
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