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Q6GBX4 (DHPS_STAAS) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydropteroate synthase

Short name=DHPS
EC=2.5.1.15
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene names
Name:folP
Ordered Locus Names:SAS0471
OrganismStaphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]
Taxonomic identifier282459 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activity

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the DHPS family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Dihydropteroate synthase
PRO_0000168224

Regions

Domain1 – 251251Pterin-binding
Region51 – 522Substrate binding By similarity

Sites

Metal binding111Magnesium By similarity
Binding site191Substrate By similarity
Binding site841Substrate By similarity
Binding site1031Substrate By similarity
Binding site1671Substrate By similarity
Binding site2031Substrate By similarity
Binding site2391Substrate By similarity
Binding site2411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GBX4 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 2239DA215DE7BB6E

FASTA26729,551
        10         20         30         40         50         60 
MTKTKIMGIL NVTPDSFSDG GKFNNVESAI NRVKAMIDEG VDIIDVGGVS TRPGHEMVSL 

        70         80         90        100        110        120 
EEEMNRVLPV VEAIVGFDVK ISVDTFRSEV AEACLKLGVD MINDQWAGLY DHRMFQIVAK 

       130        140        150        160        170        180 
YDAEIILMHN GNGNRDEPVV EEMLTSLLAQ AHQAKIAGIP SNKIWLDPGI GFAKTRNEEA 

       190        200        210        220        230        240 
EVMARLDELV ATEYPVLLAT SRKRFTKEMM GYDTTPVERD EVTAATTAYG IMKGVRAVRV 

       250        260 
HNVELNAKLA KGIDFLKENE NARHNLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571857 Genomic DNA. Translation: CAG42246.1.
RefSeqYP_042599.1. NC_002953.3.

3D structure databases

ProteinModelPortalQ6GBX4.
SMRQ6GBX4. Positions 2-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING282459.SAS0471.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2863349.
KEGGsas:SAS0471.
PATRIC19550316. VBIStaAur96780_0492.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0294.
HOGENOMHOG000217509.
KOK00796.
OMASIDTYHA.
OrthoDBEOG67T5P5.
ProtClustDBCLSK884705.

Enzyme and pathway databases

UniPathwayUPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHPS_STAAS
AccessionPrimary (citable) accession number: Q6GBX4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 19, 2004
Last modified: November 13, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways