Q6GBV9 (CYSE_STAAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine acetyltransferase
Short name=SAT
EC=2.3.1.30

Gene names

Name:	cysE
Ordered Locus Names:	SAS0486

Organism

Staphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]

Taxonomic identifier

282459 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Serine acetyltransferase		PRO_0000068681

Sequences

	Sequence		Length	Mass (Da)
	Q6GBV9 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 9FBD3FB9144C10E2	FASTA	215	23,754
	10 20 30 40 50 60 MILLKRMRDD IKMVFEQDPA ARSTLEVITT YAGLHAVWSH LIAHKLYNQK KYVAARAISQ 70 80 90 100 110 120 ISRFFTGIEI HPGAKIGKRL FIDHGMGVVI GETCTIGDNV TIYQGVTLGG TGKERGKRHP 130 140 150 160 170 180 DIGDNVLIAA GAKVLGNIKI NSNVNIGANS VVLQSVPSYS TVVGIPGHIV KQDGVRVGKT 190 200 210 FDHRHLPDPI YEQIKHLERQ LEKTRNGEIQ DDYII

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MSSA476.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571857 Genomic DNA. Translation: CAG42261.1.
RefSeq	YP_042614.1. NC_002953.3.
3D structure databases
ProteinModelPortal	Q6GBV9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GBV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000022641; EBSTAP00000021808; EBSTAG00000022640.
GeneID	2864217.
GenomeReviews	Gene locus SAS0486 in contig BX571857_GR.
KEGG	sas:SAS0486.
PATRIC	19550380. VBIStaAur96780_0508.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1045.
GeneTree	EBGT00050000024445.
HOGENOM	HBG754554.
OMA	GGTGKSH.
ProtClustDB	CLSK884712.
Enzyme and pathway databases
BioCyc	SAUR282459:SAS0486-MONOMER.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR005881. Ser_O-AcTrfase. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00640.
Pfam	PF00132. Hexapep. 2 hits. [Graphical view]
PIRSF	PIRSF000441. CysE. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01172. CysE. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSE_STAAS

Accession

Primary (citable) accession number: Q6GBV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program