Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6GAU3 (FABH_STAAS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:SAS0853
OrganismStaphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]
Taxonomic identifier282459 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3133133-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_0000110472

Regions

Region239 – 2435ACP-binding By similarity

Sites

Active site1121 By similarity
Active site2381 By similarity
Active site2681 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GAU3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 325F4A9CFF461769

FASTA31333,879
        10         20         30         40         50         60 
MNVGIKGFGA YAPEKIIDNA YFEQFLDTSD EWISKMTGIK ERHWADDDQD TSDLAYEASL 

        70         80         90        100        110        120 
KAIADAGIQP EDIDMIIVAT ATGDMPFPTV ANMLQERLGT GKVASMDQLA ACSGFMYSMI 

       130        140        150        160        170        180 
TAKQYVQSGD YHNILVVGAD KLSKITDLTD RSTAVLFGDG AGAVIIGEVS DGRGIISYEM 

       190        200        210        220        230        240 
GSDGTGGKHL YLDKDTGKLK MNGREVFKFA VRIMGDASTR VVEKANLTSD DIDLFIPHQA 

       250        260        270        280        290        300 
NIRIMESARE RLGISKDKMS VSVNKYGNTS AASIPLSIDQ ELKNGKIKDD DTIVLVGFGG 

       310 
GLTWGAMTIK WGK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571857 Genomic DNA. Translation: CAG42628.1.
RefSeqYP_042980.1. NC_002953.3.

3D structure databases

ProteinModelPortalQ6GAU3.
SMRQ6GAU3. Positions 1-312.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6GAU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000023176; EBSTAP00000022343; EBSTAG00000023175.
GeneID2863616.
GenomeReviewsGene locus SAS0853 in contig BX571857_GR.
KEGGsas:SAS0853.
PATRIC19551138. VBIStaAur96780_0889.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
GeneTreeEBGT00050000025246.
HOGENOMHBG649927.
OMAKEIGAIN.
PhylomeDBQ6GAU3.
ProtClustDBPRK09352.

Enzyme and pathway databases

BioCycSAUR282459:SAS0853-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Other

BindingDBQ6GAU3.

Entry information

Entry nameFABH_STAAS
AccessionPrimary (citable) accession number: Q6GAU3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents