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Q6GAT0

- SYW_STAAS

UniProt

Q6GAT0 - SYW_STAAS

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei196 – 1961ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:SAS0866
    OrganismiStaphylococcus aureus (strain MSSA476)
    Taxonomic identifieri282459 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002201: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Tryptophan--tRNA ligasePRO_0000136679Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi282459.SAS0866.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GAT0.
    SMRiQ6GAT0. Positions 1-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi10 – 189"HIGH" region
    Motifi193 – 1975"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059940.
    KOiK01867.
    OMAiIDPKKHI.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GAT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    METLFSGIQP SGIPTIGNYI GALKQFVDVQ NDYDCYFCIV DQHAITMPQD    50
    RLKLRKQTRQ LAAIYLASGI DPDKATLFIQ SEVPAHVQAG WMLTTIASVG 100
    ELERMTQYKD KAQKAVEGIP AGLLTYPPLM AADIVLYNTN IVPVGDDQKQ 150
    HIELTRNLVD RFNSRYNDVL VKPEIRMPKV GGRVMSLQDP TRKMSKSDDN 200
    AKNFISLLDE PNVAAKKIKS AVTDSDGIIK FDRDNKPGIT NLISIYAGLT 250
    DMPIKDIEAK YEGEGYGKFK GDLAEIVKAF LVEFQEKYES FYNSDKLDDI 300
    LDQGRDKAHK VSFKTVKKME KAMGLGRKR 329
    Length:329
    Mass (Da):36,909
    Last modified:July 19, 2004 - v1
    Checksum:i5F55F1B897FA0291
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571857 Genomic DNA. Translation: CAG42641.1.
    RefSeqiYP_042993.1. NC_002953.3.

    Genome annotation databases

    GeneIDi2862592.
    KEGGisas:SAS0866.
    PATRICi19551164. VBIStaAur96780_0902.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571857 Genomic DNA. Translation: CAG42641.1 .
    RefSeqi YP_042993.1. NC_002953.3.

    3D structure databases

    ProteinModelPortali Q6GAT0.
    SMRi Q6GAT0. Positions 1-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282459.SAS0866.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2862592.
    KEGGi sas:SAS0866.
    PATRICi 19551164. VBIStaAur96780_0902.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059940.
    KOi K01867.
    OMAi IDPKKHI.
    OrthoDBi EOG686NJQ.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSSA476.

    Entry informationi

    Entry nameiSYW_STAAS
    AccessioniPrimary (citable) accession number: Q6GAT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3