Q6G9R2 (GLPD_STAAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aerobic glycerol-3-phosphate dehydrogenase
EC=1.1.5.3

Gene names

Name:	glpD
Ordered Locus Names:	SAS1234

Organism

Staphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]

Taxonomic identifier

282459 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor	FAD By similarity.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
Sequence caution	The sequence CAG43012.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Glycerol metabolism
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycerol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Aerobic glycerol-3-phosphate dehydrogenase		PRO_0000270063
Regions
	Nucleotide binding	21 – 49	29	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6G9R2 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: BB3D044040212E82	FASTA	557	62,388
	10 20 30 40 50 60 MALSTFKREH IKKNLRNDEY DLVIIGGGIT GAGIALDASE RGMKVALVEM QDFAQGTSSR 70 80 90 100 110 120 STKLVHGGLR YLKQFQIGVV AETGKERAIV YENGPHVTTP EWMLLPMHKG GTFGKFSTSI 130 140 150 160 170 180 GLGMYDRLAG VKKSERKKML SKKETLAKEP LVKKEGLKGG GYYVEYRTDD ARLTIEVMKR 190 200 210 220 230 240 AAEKGAEIIN YTKSEHFTYD KNQQVNGVKV IDKLTNENYT IKAKKVVNAA GPWVDDVRSG 250 260 270 280 290 300 DYARNNKKLR LTKGVHVVID QSKFPLGQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD 310 320 330 340 350 360 NIKSSPLTTQ EDRDYLIDAI NYMFPSVNVT DEDIESTWAG IRPLIYEEGK DPSEISRKDE 370 380 390 400 410 420 IWEGKSGLLT IAGGKLTGYR HMAQDIVDLV SKRLKKDYGL TFSPCNTKGL AISGGDVGGS 430 440 450 460 470 480 KNFDAFVEQK VDVAKGFGID EDVARRLASK YGSNVDELFN IAQTSQYHDS KLPLEIYVEL 490 500 510 520 530 540 VYSIQQEMVY KPNDFLVRRS GKMYFNIKDV LDYKDAVIDI MADMLDYSPA QIEAYTEEVE 550 QAIKEAQHGN NQPAVKE

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MSSA476.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571857 Genomic DNA. Translation: CAG43012.1. Different initiation.
RefSeq	YP_043361.1. NC_002953.3.
3D structure databases
ProteinModelPortal	Q6G9R2.
SMR	Q6G9R2. Positions 3-546.
ModBase	Search...
Protein-protein interaction databases
STRING	282459.SAS1234.
Proteomic databases
PRIDE	Q6G9R2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2863533.
KEGG	sas:SAS1234.
PATRIC	19551935. VBIStaAur96780_1285.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0578.
HOGENOM	HOG000004812.
KO	K00111.
ProtClustDB	CLSK872929.
Enzyme and pathway databases
UniPathway	UPA00618; UER00674.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR000447. G3P_DH_FAD-dep. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR01001. FADG3PDH.
PROSITE	PS00977. FAD_G3PDH_1. 1 hit. PS00978. FAD_G3PDH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPD_STAAS

Accession

Primary (citable) accession number: Q6G9R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program