Reviewed, UniProtKB/Swiss-Prot Q6G9J4 (TYRA_STAAS)

Names and origin

Protein names

Recommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	SAS1305

Organism

Staphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]

Taxonomic identifier

282459 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
Sequence similarities	Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Prephenate dehydrogenase		PRO_0000282657
Regions
	Domain	2 – 291	290	Prephenate/arogenate dehydrogenase
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6G9J4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 8F16333DC3B816C6	FASTA	363	40,395
	10 20 30 40 50 60 MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE KCLNYSEAIK 70 80 90 100 110 120 KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA MIQQHECNLL KHNIHLVSGH 130 140 150 160 170 180 PMAGSHKSGV LNAKKHLFEN AYYILVYNEP RNEQAANTLK ELLSPTLAKF IVTTAEEHDY 190 200 210 220 230 240 VTSVVSHLPH IVASSLVHVS QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK 250 260 270 280 290 300 TYILEMIRQL KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 310 320 330 340 350 360 IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER GMQALSDFDC YIQ

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571857 Genomic DNA. Translation: CAG43082.1.
RefSeq	YP_043429.1.
3D structure databases
HSSP	HSSP built from PDB template 2G5C based on UniProtKB O67636.
SMR	Q6G9J4. Positions 3-295.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6G9J4.
Genome annotation databases
GeneID	2861989.
GenomeReviews	Gene locus SAS1305 in contig BX571857_GR.
KEGG	sas:SAS1305.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0287.
HOGENOM	HBG544990.
OMA	QRAIRWG.
Enzyme and pathway databases
BioCyc	SAUR282459:SAS1305-MONOMER.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF02153. PDH. 1 hit. [Graphical view]
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_STAAS

Accession

Primary (citable) accession number: Q6G9J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)