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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:SAS1474
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669741 – 451Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST451

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6G930
SMRiQ6G930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIVSHRYIP LTEKDKQEML QTIGAKSIGE LFGDVPSDIL LNRDLNIAEG
60 70 80 90 100
EAETTLLRRL NRIASKNITK ETHTSFLGAG VYDHYAPSVV DAMISRSEFY
110 120 130 140 150
TAYTPYQPEI SQGELQAIFE FQTLICELTD MDVANSSMYD GMTSFAEACI
160 170 180 190 200
LAFSQTKKNK IVVSKGLHYQ ALQVLHTYAK TRKEFEVVEI DLDGTVTDLK
210 220 230 240 250
KLEAAVDDET AAVAVQYPNF YGSIEDLEKI HSFIEDKKAL FIVYANPLAL
260 270 280 290 300
GLLTPPGSFG ADIVVGDTQP FGIPAQFGGP HCGYFATTKK LMRKVPGRLV
310 320 330 340 350
GQTQDDEGNR GFVLTLQARE QHIRRDKATS NICSNQALNA LASSIAMSAL
360 370 380 390 400
GKQGIYDIAV QNIEHANYAK QQFIKKGFEV LDGTSFNEFV VKFDKPIQQV
410 420 430 440 450
NEELVKYNII GGFDLGVVSD DFKNHMLIAV TELRTKDEID TFVEKAGELN

D
Length:451
Mass (Da):50,032
Last modified:July 19, 2004 - v1
Checksum:iA681F1B85C8BDCB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA Translation: CAG43269.1

Genome annotation databases

KEGGisas:SAS1474

Similar proteinsi

Entry informationi

Entry nameiGCSPA_STAAS
AccessioniPrimary (citable) accession number: Q6G930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 19, 2004
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health