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Q6G8T5 (RELA_STAAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP pyrophosphokinase
EC=2.7.6.5
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene names
Name:relA
Ordered Locus Names:SAS1570
OrganismStaphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]
Taxonomic identifier282459 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length736 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp By similarity.

Catalytic activity

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.

Sequence similarities

Belongs to the RelA/SpoT family.

Contains 1 ACT domain.

Contains 1 HD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 736736GTP pyrophosphokinase
PRO_0000166558

Regions

Domain57 – 156100HD
Domain661 – 73474ACT

Sequences

Sequence LengthMass (Da)Tools
Q6G8T5 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: C1EC881D00431801

FASTA73684,537
        10         20         30         40         50         60 
MNGVYHIMNN EYPYSADEVL HKAKSYLSAD EYEYVLKSYH IAYEAHKGQF RKNGLPYIMH 

        70         80         90        100        110        120 
PIQVAGILTE MRLDGPTIVA GFLHDVIEDT PYTFEDVKEM FNEEVARIVD GVTKLKKVKY 

       130        140        150        160        170        180 
RSKEEQQAEN HRKLFIAIAK DVRVILVKLA DRLHNMRTLK AMPREKQIRI SRETLEIYAP 

       190        200        210        220        230        240 
LAHRLGINTI KWELEDTALR YIDNVQYFRI VNLMKKKRSE REAYIETAID RIRTEMDRMN 

       250        260        270        280        290        300 
IEGDINGRPK HIYSIYRKMM KQKKQFDQIF DLLAIRVIVN SINDCYAILG LVHTLWKPMP 

       310        320        330        340        350        360 
GRFKDYIAMP KQNLYQSLHT TVVGPNGDPL EIQIRTFDMH EIAEHGVAAH WAYKEGKKVS 

       370        380        390        400        410        420 
EKDQTYQNKL NWLKELAEAD HTSSDAQEFM ETLKYDLQSD KVYAFTPASD VIELPYGAVP 

       430        440        450        460        470        480 
IDFAYAIHSE VGNKMIGAKV NGKIVPIDYI LQTGDIVEIR TSKHSYGPSR DWLKIVKSSS 

       490        500        510        520        530        540 
AKGKIKSFFK KQDRSSNIEK GRMMVEVEIK EQGFRVEDIL TEKNIQVVNE KYNFANEDDL 

       550        560        570        580        590        600 
FAAVGFGGVT SLQIVNKLTE RQRILDKQRA LNEAQEVTKS LPIKDNIITD SGVYVEGLEN 

       610        620        630        640        650        660 
VLIKLSKCCN PIPGDDIVGY ITKGHGIKVH RTDCPNIKNE TERLINVEWV KSKDATQKYQ 

       670        680        690        700        710        720 
VDLEVTAYDR NGLLNEVLQA VSSTAGNLIK VSGRSDIDKN AIINISVMVK NVNDVYRVVE 

       730 
KIKQLGDVYT VTRVWN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571857 Genomic DNA. Translation: CAG43371.1.
RefSeqYP_043688.1. NC_002953.3.

3D structure databases

ProteinModelPortalQ6G8T5.
SMRQ6G8T5. Positions 14-357.
ModBaseSearch...

Protein-protein interaction databases

STRING282459.SAS1570.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2862969.
KEGGsas:SAS1570.
PATRIC19552625. VBIStaAur96780_1631.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0317.
HOGENOMHOG000018301.
KOK00951.
OMALSWFREI.
ProtClustDBCLSK885475.

Enzyme and pathway databases

UniPathwayUPA00908; UER00884.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR026020. (p)ppGpp_Synthase.
IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PANTHERPTHR21262. PTHR21262. 1 hit.
PfamPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMSSF81271. TGS-like. 1 hit.
TIGRFAMsTIGR00691. spoT_relA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRELA_STAAS
AccessionPrimary (citable) accession number: Q6G8T5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 19, 2004
Last modified: May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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