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Q6G8G9 (SYL_STAAS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:SAS1684
OrganismStaphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]
Taxonomic identifier282459 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 806806Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152086

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif578 – 5825"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5811ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6G8G9 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 6063BAAE9233B62B

FASTA80691,871
        10         20         30         40         50         60 
MNYNHNQIEK KWQDYWDENK TFKTNDNLGQ KKFYALDMFP YPSGAGLHVG HPEGYTATDI 

        70         80         90        100        110        120 
ISRYKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT KKNIQTFKRQ IKELGFSYDW 

       130        140        150        160        170        180 
DREVNTTDPE YYKWTQWIFI QLYNKGLAYV DEVAVNWCPA LGTVLSNEEV IDGVSERGGH 

       190        200        210        220        230        240 
PVYRKPMKQW VLKITEYADQ LLADLDDLDW PESLKDMQRN WIGRSEGAKV SFDVDNTEAE 

       250        260        270        280        290        300 
GKVEVFTTRP DTIYGASFLV LSPEHALVNS ITTDEYKEKV KAYQTEASKK SDLERTDLAK 

       310        320        330        340        350        360 
DKSGVFTGAY AINPLSGEKV QIWIADYVLS TYGTGAIMAV PAHDDRDYEF AKKFDLPIIE 

       370        380        390        400        410        420 
VIEGGNVEEA AYTGEGKHIN SGELDGLENE AAITKAIQLL EQKGAGEKKV NYKLRDWLFS 

       430        440        450        460        470        480 
RQRYWGEPIP VIHWEDGTMT TVPEEELPLL LPETDEIKPS GTGESPLANI DSFVNVVDEK 

       490        500        510        520        530        540 
TGMKGRRETN TMPQWAGSCW YYLRYIDPKN ENMLADPEKL KHWLPVDLYI GGVEHAVLHL 

       550        560        570        580        590        600 
LYARFWHKVL YDLGIVPTKE PFQKLFNQGM ILGEGNEKMS KSKGNVINPD DIVQSHGADT 

       610        620        630        640        650        660 
LRLYEMFMGP LDAAIAWSEK GLDGSRRFLD RVWRLMVNED GTLSSKIVTT NNKSLDKVYN 

       670        680        690        700        710        720 
QTVKKVTEDF ETLGFNTAIS QLMVFINECY KVDEVYKPYI EGFVKMLAPI APHIGEELWS 

       730        740        750        760        770        780 
KLGHEESITY QPWPTYDEAL LVDDEVEIVV QVNGKLRAKI KIAKDTSKEE MQEIALSNDN 

       790        800 
VKASIEGKDI MKVIAVPQKL VNIVAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571857 Genomic DNA. Translation: CAG43487.1.
RefSeqYP_043804.1. NC_002953.3.

3D structure databases

ProteinModelPortalQ6G8G9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING282459.SAS1684.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2862510.
KEGGsas:SAS1684.
PATRIC19552861. VBIStaAur96780_1749.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_STAAS
AccessionPrimary (citable) accession number: Q6G8G9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries