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Q6G7Q2

- ILVC_STAAS

UniProt

Q6G7Q2 - ILVC_STAAS

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Protein
Ketol-acid reductoisomerase
Gene
ilvC, SAS1961
Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071 Reviewed prediction

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomerase (EC:1.1.1.86)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvC
Ordered Locus Names:SAS1961
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002201: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Ketol-acid reductoisomeraseUniRule annotation
PRO_0000151359Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi282459.SAS1961.

Structurei

3D structure databases

ProteinModelPortaliQ6G7Q2.
SMRiQ6G7Q2. Positions 3-327.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0059.
HOGENOMiHOG000016230.
KOiK00053.
OMAiRFAKDFI.
OrthoDBiEOG625K07.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G7Q2-1 [UniParc]FASTAAdd to Basket

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MTTVYYDQDV KTDALQGKKI AVVGYGSQGH AHAQNLKDNG YDVVIGIRPG    50
RSFDKAKEDG FDVFPVAEAV KQADVIMVLL PDEIQGDVYK NEIEPNLEKH 100
NALAFAHGFN IHFGVIQPPA DVDVFLVAPK GPGHLVRRTF VEGSAVPSLF 150
GIQQDASGQA RNIALSYAKG IGATRAGVIE TTFKEETETD LFGEQAVLCG 200
GVSKLIQSGF ETLVEAGYQP ELAYFEVLHE MKLIVDLMYE GGTENVRYSI 250
SNTAEFGDYV SGPRVITPDV KENMKAVLTD IQNGNFSNRF IEDNKNGFKE 300
FYKLREEQHG HQIEKVGREL REMMPFIKSK SIEK 334
Length:334
Mass (Da):36,984
Last modified:July 19, 2004 - v1
Checksum:iD6B48BE5B5598859
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571857 Genomic DNA. Translation: CAG43768.1.
RefSeqiYP_044071.1. NC_002953.3.

Genome annotation databases

GeneIDi2861757.
KEGGisas:SAS1961.
PATRICi19553521. VBIStaAur96780_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571857 Genomic DNA. Translation: CAG43768.1 .
RefSeqi YP_044071.1. NC_002953.3.

3D structure databases

ProteinModelPortali Q6G7Q2.
SMRi Q6G7Q2. Positions 3-327.
ModBasei Search...

Protein-protein interaction databases

STRINGi 282459.SAS1961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2861757.
KEGGi sas:SAS1961.
PATRICi 19553521. VBIStaAur96780_2042.

Phylogenomic databases

eggNOGi COG0059.
HOGENOMi HOG000016230.
KOi K00053.
OMAi RFAKDFI.
OrthoDBi EOG625K07.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSSA476.

Entry informationi

Entry nameiILVC_STAAS
AccessioniPrimary (citable) accession number: Q6G7Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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