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Q6G7Q2

- ILVC_STAAS

UniProt

Q6G7Q2 - ILVC_STAAS

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071UniRule annotation

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:SAS1961
    OrganismiStaphylococcus aureus (strain MSSA476)
    Taxonomic identifieri282459 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002201: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Ketol-acid reductoisomerasePRO_0000151359Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi282459.SAS1961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6G7Q2.
    SMRiQ6G7Q2. Positions 3-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0059.
    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiRFAKDFI.
    OrthoDBiEOG625K07.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6G7Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTVYYDQDV KTDALQGKKI AVVGYGSQGH AHAQNLKDNG YDVVIGIRPG    50
    RSFDKAKEDG FDVFPVAEAV KQADVIMVLL PDEIQGDVYK NEIEPNLEKH 100
    NALAFAHGFN IHFGVIQPPA DVDVFLVAPK GPGHLVRRTF VEGSAVPSLF 150
    GIQQDASGQA RNIALSYAKG IGATRAGVIE TTFKEETETD LFGEQAVLCG 200
    GVSKLIQSGF ETLVEAGYQP ELAYFEVLHE MKLIVDLMYE GGTENVRYSI 250
    SNTAEFGDYV SGPRVITPDV KENMKAVLTD IQNGNFSNRF IEDNKNGFKE 300
    FYKLREEQHG HQIEKVGREL REMMPFIKSK SIEK 334
    Length:334
    Mass (Da):36,984
    Last modified:July 19, 2004 - v1
    Checksum:iD6B48BE5B5598859
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571857 Genomic DNA. Translation: CAG43768.1.
    RefSeqiYP_044071.1. NC_002953.3.

    Genome annotation databases

    GeneIDi2861757.
    KEGGisas:SAS1961.
    PATRICi19553521. VBIStaAur96780_2042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571857 Genomic DNA. Translation: CAG43768.1 .
    RefSeqi YP_044071.1. NC_002953.3.

    3D structure databases

    ProteinModelPortali Q6G7Q2.
    SMRi Q6G7Q2. Positions 3-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282459.SAS1961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2861757.
    KEGGi sas:SAS1961.
    PATRICi 19553521. VBIStaAur96780_2042.

    Phylogenomic databases

    eggNOGi COG0059.
    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi RFAKDFI.
    OrthoDBi EOG625K07.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSSA476.

    Entry informationi

    Entry nameiILVC_STAAS
    AccessioniPrimary (citable) accession number: Q6G7Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3