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Protein

4,4'-diaponeurosporen-aldehyde dehydrogenase

Gene

aldH

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'-diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid.By similarity

Catalytic activityi

4,4'-diaponeurosporenal + NAD+ + H2O = 4,4'-diaponeurosporenoate + NADH.By similarity

Pathwayi: staphyloxanthin biosynthesis

This protein is involved in the subpathway that synthesizes staphyloxanthin from farnesyl diphosphate.By similarity This subpathway is part of the pathway staphyloxanthin biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway staphyloxanthin biosynthesis and in Carotenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei245Proton acceptorBy similarity1
Binding sitei246NAD; via carbonyl oxygenBy similarity1
Active sitei279NucleophileBy similarity1
Binding sitei379NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi146 – 147NADBy similarity2
Nucleotide bindingi223 – 224NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarotenoid biosynthesis, Virulence
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
4,4'-diaponeurosporen-aldehyde dehydrogenaseBy similarity (EC:1.2.1.-By similarity)
Alternative name(s):
4,4'-diaponeurosporenal dehydrogenaseBy similarity
Gene namesi
Name:aldHBy similarity
Ordered Locus Names:SAS2025
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002935551 – 4754,4'-diaponeurosporen-aldehyde dehydrogenaseAdd BLAST475

Structurei

3D structure databases

ProteinModelPortaliQ6G7I8.
SMRiQ6G7I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000271505.
KOiK00128.
OMAiRHVMIKH.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G7I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA
60 70 80 90 100
ADNVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE
110 120 130 140 150
RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPKK IKDAFLAELK
310 320 330 340 350
EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS
460 470
GLGREWGDYG IEEFLEVKSI AGYFK
Length:475
Mass (Da):51,982
Last modified:July 19, 2004 - v1
Checksum:i6D8F555E7F35D4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG43833.1.
RefSeqiWP_001206105.1. NC_002953.3.

Genome annotation databases

KEGGisas:SAS2025.

Similar proteinsi

Entry informationi

Entry nameiALDH_STAAS
AccessioniPrimary (citable) accession number: Q6G7I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program