Q6G7C1 (LACC_STAAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tagatose-6-phosphate kinase
EC=2.7.1.144

Alternative name(s):
Phosphotagatokinase

Gene names

Name:	lacC
Ordered Locus Names:	SAS2094

Organism

Staphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]

Taxonomic identifier

282459 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. HAMAP-Rule MF_01557
Pathway	Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2. HAMAP-Rule MF_01557
Sequence similarities	Belongs to the carbohydrate kinase PfkB family. LacC subfamily.

Ontologies

Keywords
Biological process	Lactose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-tagatose 6-phosphate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tagatose-6-phosphate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Tagatose-6-phosphate kinase HAMAP-Rule MF_01557		PRO_0000203919

Sequences

	Sequence		Length	Mass (Da)
	Q6G7C1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: D8A085EA1BD60543	FASTA	310	33,853
	10 20 30 40 50 60 MILTLTLNPS VDISYPLTAL KLDDVNRVQE VSKTAGGKGL NVTRVLAQVG EPVLASGFIG 70 80 90 100 110 120 GELGQFIAKK LDHADIKHAF YNIKGETRNC IAILHEGQQT EILEQGPEID NQEAAGFIKH 130 140 150 160 170 180 FEQLLEKVEA VAISGSLPKG LNQDYYAQII ERCQNKGVPV ILDCSGATLQ TVLENPYKPT 190 200 210 220 230 240 VIKPNISELY QLLNQPLDES LESLKQAVSQ PLFEGIEWII VSLGAQGAFA KHNHTFYRVN 250 260 270 280 290 300 IPTISVLNPV GSGDSTVAGI TSAILNHEND HDLLKKANTL GMLNAQEAQT GYVNLNNYDD 310 LFNQIEVLEV

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MSSA476.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571857 Genomic DNA. Translation: CAG43902.1.
RefSeq	YP_044203.1. NC_002953.3.
3D structure databases
ProteinModelPortal	Q6G7C1.
SMR	Q6G7C1. Positions 1-310.
ModBase	Search...
Protein-protein interaction databases
STRING	282459.SAS2094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2862754.
KEGG	sas:SAS2094.
PATRIC	19553817. VBIStaAur96780_2176.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1105.
HOGENOM	HOG000265280.
KO	K00917.
OMA	KGLNVCR.
ProtClustDB	PRK13508.
Enzyme and pathway databases
UniPathway	UPA00704; UER00715.
Family and domain databases
HAMAP	MF_01557. LacC.
InterPro	IPR002173. Carboh/pur_kinase_PfkB_CS. IPR005926. LacC. IPR011611. PfkB_dom. IPR017583. Tagatose/fructose_Pkinase. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PIRSF	PIRSF000535. 1PFK/6PFK/LacC. 1 hit.
TIGRFAMs	TIGR03168. 1-PFK. 1 hit. TIGR01231. lacC. 1 hit.
PROSITE	PS00583. PFKB_KINASES_1. 1 hit. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LACC_STAAS

Accession

Primary (citable) accession number: Q6G7C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program