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Protein

Molybdopterin synthase catalytic subunit

Gene

moaE

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).By similarity

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44SubstrateBy similarity1
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00344

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunit (EC:2.8.1.12)
Alternative name(s):
MPT synthase subunit 2
Molybdenum cofactor biosynthesis protein E
Molybdopterin-converting factor large subunit
Molybdopterin-converting factor subunit 2
Gene namesi
Name:moaE
Ordered Locus Names:SAS2161
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001631011 – 148Molybdopterin synthase catalytic subunitAdd BLAST148

Interactioni

Subunit structurei

Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6G751
SMRiQ6G751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 36Substrate bindingBy similarity3
Regioni100 – 101Substrate bindingBy similarity2
Regioni123 – 125Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the MoaE family.Curated

Phylogenomic databases

HOGENOMiHOG000280877
KOiK03635
OMAiWKKEMYE

Family and domain databases

CDDicd00756 MoaE, 1 hit
Gene3Di3.90.1170.40, 1 hit
InterProiView protein in InterPro
IPR036563 MoaE_sf
IPR003448 Mopterin_biosynth_MoaE
PfamiView protein in Pfam
PF02391 MoaE, 1 hit
SUPFAMiSSF54690 SSF54690, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQFEIVTEP IQTEQYREFT INEYQGAVVV FTGHVREWTK GVKTEYLEYE
60 70 80 90 100
AYIPMAEKKL AQIGDEINEK WPGTITSIVH RIGPLQISDI AVLIAVSSPH
110 120 130 140
RKDAYRANEY AIERIKEIVP IWKKEIWEDG SKWQGHQKGN YEEAKREE
Length:148
Mass (Da):17,339
Last modified:July 19, 2004 - v1
Checksum:iB4292F340523EA19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA Translation: CAG43972.1
RefSeqiWP_000808500.1, NC_002953.3

Genome annotation databases

KEGGisas:SAS2161

Similar proteinsi

Entry informationi

Entry nameiMOAE_STAAS
AccessioniPrimary (citable) accession number: Q6G751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health