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Protein

Molybdopterin synthase catalytic subunit

Gene

moaE

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).By similarity

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44SubstrateBy similarity1
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunit (EC:2.8.1.12)
Alternative name(s):
MPT synthase subunit 2
Molybdenum cofactor biosynthesis protein E
Molybdopterin-converting factor large subunit
Molybdopterin-converting factor subunit 2
Gene namesi
Name:moaE
Ordered Locus Names:SAS2161
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001631011 – 148Molybdopterin synthase catalytic subunitAdd BLAST148

Interactioni

Subunit structurei

Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6G751.
SMRiQ6G751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 36Substrate bindingBy similarity3
Regioni100 – 101Substrate bindingBy similarity2
Regioni123 – 125Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the MoaE family.Curated

Phylogenomic databases

HOGENOMiHOG000280877.
KOiK03635.
OMAiSKDGSYW.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
InterProiIPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQFEIVTEP IQTEQYREFT INEYQGAVVV FTGHVREWTK GVKTEYLEYE
60 70 80 90 100
AYIPMAEKKL AQIGDEINEK WPGTITSIVH RIGPLQISDI AVLIAVSSPH
110 120 130 140
RKDAYRANEY AIERIKEIVP IWKKEIWEDG SKWQGHQKGN YEEAKREE
Length:148
Mass (Da):17,339
Last modified:July 19, 2004 - v1
Checksum:iB4292F340523EA19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG43972.1.
RefSeqiWP_000808500.1. NC_002953.3.

Genome annotation databases

GeneIDi28380124.
KEGGisas:SAS2161.
PATRICi19553957. VBIStaAur96780_2246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG43972.1.
RefSeqiWP_000808500.1. NC_002953.3.

3D structure databases

ProteinModelPortaliQ6G751.
SMRiQ6G751.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi28380124.
KEGGisas:SAS2161.
PATRICi19553957. VBIStaAur96780_2246.

Phylogenomic databases

HOGENOMiHOG000280877.
KOiK03635.
OMAiSKDGSYW.

Enzyme and pathway databases

UniPathwayiUPA00344.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
InterProiIPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOAE_STAAS
AccessioniPrimary (citable) accession number: Q6G751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.