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Protein

Gamma-hemolysin component A

Gene

hlgA

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component A
Alternative name(s):
H-gamma-2
H-gamma-II
Gene namesi
Name:hlgA
Ordered Locus Names:SAS2310
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000004521630 – 309Gamma-hemolysin component AAdd BLAST280

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgA (class S) associates with HlgB (class F) thus forming an AB toxin in strains producing both gamma-hemolysins and leukocidins. HlgA and LukF-PV can also form a complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6G6Q2
SMRiQ6G6Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000280105
KOiK11038
OMAiMAPLANP

Family and domain databases

InterProiView protein in InterPro
IPR003963 Bi-component_toxin_staph
IPR016183 Leukocidin/Hemolysin_toxin
IPR036435 Leukocidin/porin_MspA_sf
PfamiView protein in Pfam
PF07968 Leukocidin, 1 hit
PRINTSiPR01468 BICOMPNTOXIN
SUPFAMiSSF56959 SSF56959, 1 hit
TIGRFAMsiTIGR01002 hlyII, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6G6Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNKILTAT LAVGLIAPLA NPFIEISKAE NKIEDIGQGA EIIKRTQDIT
60 70 80 90 100
SKRLAITQNI QFDFVKDKKY NKDALVVKMQ GFISSRTTYS DLKKYPYIKR
110 120 130 140 150
MIWPFQYNIS LKTKDSNVDL INYLPKNKID SADVSQKLGY NIGGNFQSAP
160 170 180 190 200
SIGGSGSFNY SKTISYNQKN YVTEVESQNS KGVKWGVKAN SFVTPNGQVS
210 220 230 240 250
AYDQYLFAQD PTGPAARDYF VPDNQLPPLI QSGFNPSFIT TLSHERGKGD
260 270 280 290 300
KSEFEITYGR NMDATYAYVT RHRLAVDRKH DAFKNRNVTV KYEVNWKTHE

VKIKSITPK
Length:309
Mass (Da):34,956
Last modified:July 19, 2004 - v1
Checksum:i15CAE12E1025B616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA Translation: CAG44123.1
RefSeqiWP_000594519.1, NC_002953.3

Genome annotation databases

KEGGisas:SAS2310

Similar proteinsi

Entry informationi

Entry nameiHLGA_STAAS
AccessioniPrimary (citable) accession number: Q6G6Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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