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Protein

Gamma-hemolysin component A

Gene

hlgA

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-hemolysin component A
Alternative name(s):
H-gamma-2
H-gamma-II
Gene namesi
Name:hlgA
Ordered Locus Names:SAS2310
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000004521630 – 309Gamma-hemolysin component AAdd BLAST280

Interactioni

Subunit structurei

Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgA (class S) associates with HlgB (class F) thus forming an AB toxin in strains producing both gamma-hemolysins and leukocidins. HlgA and LukF-PV can also form a complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6G6Q2.
SMRiQ6G6Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aerolysin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000280105.
KOiK11038.
OMAiMAPLANP.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6G6Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNKILTAT LAVGLIAPLA NPFIEISKAE NKIEDIGQGA EIIKRTQDIT
60 70 80 90 100
SKRLAITQNI QFDFVKDKKY NKDALVVKMQ GFISSRTTYS DLKKYPYIKR
110 120 130 140 150
MIWPFQYNIS LKTKDSNVDL INYLPKNKID SADVSQKLGY NIGGNFQSAP
160 170 180 190 200
SIGGSGSFNY SKTISYNQKN YVTEVESQNS KGVKWGVKAN SFVTPNGQVS
210 220 230 240 250
AYDQYLFAQD PTGPAARDYF VPDNQLPPLI QSGFNPSFIT TLSHERGKGD
260 270 280 290 300
KSEFEITYGR NMDATYAYVT RHRLAVDRKH DAFKNRNVTV KYEVNWKTHE

VKIKSITPK
Length:309
Mass (Da):34,956
Last modified:July 19, 2004 - v1
Checksum:i15CAE12E1025B616
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG44123.1.
RefSeqiWP_000594519.1. NC_002953.3.

Genome annotation databases

GeneIDi28379964.
KEGGisas:SAS2310.
PATRICi19554269. VBIStaAur96780_2403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG44123.1.
RefSeqiWP_000594519.1. NC_002953.3.

3D structure databases

ProteinModelPortaliQ6G6Q2.
SMRiQ6G6Q2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi28379964.
KEGGisas:SAS2310.
PATRICi19554269. VBIStaAur96780_2403.

Phylogenomic databases

HOGENOMiHOG000280105.
KOiK11038.
OMAiMAPLANP.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHLGA_STAAS
AccessioniPrimary (citable) accession number: Q6G6Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.