Q6G6F9 (F16PC_STAAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 3
Short name=FBPase class 3
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3

Gene names

Name:	fbp
Ordered Locus Names:	SAS2401

Organism

Staphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]

Taxonomic identifier

282459 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	654 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP-Rule MF_01854
Cofactor	Manganese By similarity. HAMAP-Rule MF_01854
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_01854
Sequence similarities	Belongs to the FBPase class 3 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 654	654	Fructose-1,6-bisphosphatase class 3 HAMAP-Rule MF_01854		PRO_0000359987

Sequences

	Sequence		Length	Mass (Da)
	Q6G6F9 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 404CE41B7168F887	FASTA	654	76,122
	10 20 30 40 50 60 MTQITEKELK KKYLDLLSQN FDTPEKLATE IINLESILEL PKGTEHFVSD LHGEYEAFQH 70 80 90 100 110 120 VLRNGSGNVR AKINDIFKER LSTKELNDLT ALVYYPEDKL KLIKSDFQSC GQLNVWYITT 130 140 150 160 170 180 IEHLIELIKY CSSKYTRSKL RKALPKQYVY IIEELLYKSN EYQNKKSYYE TLVNQVIELK 190 200 210 220 230 240 QADDLIIGLA YSVQRLVVDH LHVVGDIYDR GPQPDKIMDT LINYHSLDIQ WGNHDVLWVG 250 260 270 280 290 300 AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA EKYYDADNPA FKPKKRPDKH 310 320 330 340 350 360 ERLTQREESQ ITKIHQAIAM IQFKLEIPII KRRPNFEMEE RLVLEKVNYD TNEITVYGNT 370 380 390 400 410 420 YPLKDTCFQT VNRDNPAELL PEEEEVMNKL LLSFQQSEKL RRHMSFLMRK GSLYLPYNGN 430 440 450 460 470 480 LLIHGCIPVD ENGEMESFEI DGHTYSGQEL LDVFEYHVRK SFDEKENTDD LSTDLVWYLW 490 500 510 520 530 540 TGKYSSLFGK RAMTTFERYF IADKASHKEE KNPYYHLRED VNMVRKMLSD FGLNADEGRI 550 560 570 580 590 600 INGHTPVKEI NGEDPIKADG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHQQFN 610 620 630 640 650 AKEKILSEGI DELSIKRVVD KELQRKKIRD TNIGKDLQAQ IDILKMLMHD RYLD

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MSSA476.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571857 Genomic DNA. Translation: CAG44216.1.
RefSeq	YP_044515.1. NC_002953.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	282459.SAS2401.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2862503.
KEGG	sas:SAS2401.
PATRIC	19554457. VBIStaAur96780_2497.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3855.
HOGENOM	HOG000285784.
KO	K04041.
OMA	FVYITEE.
ProtClustDB	CLSK876712.
Enzyme and pathway databases
UniPathway	UPA00138.
Family and domain databases
HAMAP	MF_01854. FBPase_class3.
InterPro	IPR009164. FBPtase_Bacill. [Graphical view]
Pfam	PF06874. FBPase_2. 1 hit. [Graphical view]
PIRSF	PIRSF000906. FBPtase_Bacill. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F16PC_STAAS

Accession

Primary (citable) accession number: Q6G6F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program