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Protein

Carbamate kinase 2

Gene

arcC2

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

Pathwayi: carbamoyl phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Carbamate kinase 2 (arcC2), Carbamate kinase 1 (arcC1)
This subpathway is part of the pathway carbamoyl phosphate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate, the pathway carbamoyl phosphate degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00996; UER00366.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase 2 (EC:2.7.2.2)
Gene namesi
Name:arcC2
Ordered Locus Names:SAS2518
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Carbamate kinase 2PRO_0000185136Add
BLAST

Proteomic databases

PRIDEiQ6G642.

Structurei

3D structure databases

ProteinModelPortaliQ6G642.
SMRiQ6G642. Positions 3-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000277403.
KOiK00926.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKIVIALG GNAIQTKEAT AEAQQTAIRR AMQNLKPLFD SPARIVISHG
60 70 80 90 100
NGPQIGSLLI QQAKSNSDTT PAMPLDTCGA MSQGMIGYWL ETEINRILTE
110 120 130 140 150
MNSDRTVGTI VTRVEVDKDD PRFNNPTKPI GPFYTKEEVE ELQKEQPDSV
160 170 180 190 200
FKEDAGRGYR KVVASPLPQS ILEHQLIRTL ADGKNIVIAC GGGGIPVIKK
210 220 230 240 250
ENTYEGVEAV IDKDFASEKL ATLIEADTLM ILTNVENVFI NFNEPNQQQI
260 270 280 290 300
DDIDVATLKK YAAQGKFAEG SMLPKIEAAI RFVESGENKK VIITNLEQAY
310
EALIGNKGTH IHM
Length:313
Mass (Da):34,380
Last modified:March 1, 2005 - v2
Checksum:i458711BBD97E457F
GO

Sequence cautioni

The sequence CAG44335 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG44335.1. Different initiation.
RefSeqiWP_000660028.1. NC_002953.3.

Genome annotation databases

KEGGisas:SAS2518.
PATRICi19554708. VBIStaAur96780_2623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG44335.1. Different initiation.
RefSeqiWP_000660028.1. NC_002953.3.

3D structure databases

ProteinModelPortaliQ6G642.
SMRiQ6G642. Positions 3-297.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6G642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisas:SAS2518.
PATRICi19554708. VBIStaAur96780_2623.

Phylogenomic databases

HOGENOMiHOG000277403.
KOiK00926.

Enzyme and pathway databases

UniPathwayiUPA00996; UER00366.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCC2_STAAS
AccessioniPrimary (citable) accession number: Q6G642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.