Q6G5Z9 (HIS7_STAAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Imidazoleglycerol-phosphate dehydratase
Short name=IGPD
EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	SAS2561

Organism

Staphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]

Taxonomic identifier

282459 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00076.
Sequence similarities	Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076		PRO_0000158169

Sequences

	Sequence		Length	Mass (Da)
	Q6G5Z9 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 68F9A068091BA280	FASTA	192	21,456
	10 20 30 40 50 60 MIYQKQRNTA ETQLNISISD DQSPSHINTG VGFLNHMLTL FTFHSGLSLN IEAQGDIDVD 70 80 90 100 110 120 DHHVTEDIGI VIGQLLLEMI KDKKHFVRYG TMYIPMDETL ARVVVDISGR PYLSFNASLS 130 140 150 160 170 180 KEKVGTFDTE LVEEFFRAVV INARLTTHID LIRGGNTHHE IEAIFKAFSR ALGIALTATD 190 DQRVPSSKGV IE

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MSSA476.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571857 Genomic DNA. Translation: CAG44378.1.
RefSeq	YP_044675.1. NC_002953.3.
3D structure databases
ProteinModelPortal	Q6G5Z9.
SMR	Q6G5Z9. Positions 1-179.
ModBase	Search...
Protein-protein interaction databases
STRING	282459.SAS2561.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2862103.
KEGG	sas:SAS2561.
PATRIC	19554798. VBIStaAur96780_2668.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
HOGENOM	HOG000228064.
KO	K01693.
OMA	STENVVH.
ProtClustDB	PRK00951.
Enzyme and pathway databases
UniPathway	UPA00031; UER00011.
Family and domain databases
HAMAP	MF_00076. HisB.
InterPro	IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfam	PF00475. IGPD. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_STAAS

Accession

Primary (citable) accession number: Q6G5Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 19, 2004
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program