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Q6G5Z7 (HISX_STAAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:SAS2563
OrganismStaphylococcus aureus (strain MSSA476) [Complete proteome] [HAMAP]
Taxonomic identifier282459 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135851

Sites

Active site3161Proton acceptor By similarity
Active site3171Proton acceptor By similarity
Metal binding2481Zinc By similarity
Metal binding2511Zinc By similarity
Metal binding3501Zinc By similarity
Metal binding4091Zinc By similarity
Binding site1191NAD By similarity
Binding site1801NAD By similarity
Binding site2031NAD By similarity
Binding site2261Substrate By similarity
Binding site2481Substrate By similarity
Binding site2511Substrate By similarity
Binding site3171Substrate By similarity
Binding site3501Substrate By similarity
Binding site4041Substrate By similarity
Binding site4091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6G5Z7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 1BA18FA40BEEFD93

FASTA41846,389
        10         20         30         40         50         60 
MPMLNAQQFL NQFSLEAPLD ESLYPIIRDI CQEVKVHGDK ALKMYNLTFD HTKTDHLEIS 

        70         80         90        100        110        120 
HEQIKAAFDT LDEKTKQALQ QSYERIKAYQ ESIKQTNQQL EESVECYEIY HPLESVGIYV 

       130        140        150        160        170        180 
PGGKASYPST VLMTATLAQV AGVENIVVVT PPQPNGVSQE VLAACYITQV NQVFQVGGAQ 

       190        200        210        220        230        240 
SIAALTYGTE TIPKVDKIVG PGNQFVAYAK KYLFGQVGID QIAGPTEIAL IIDDTADLDA 

       250        260        270        280        290        300 
IVYDVFAQAE HDELARTYVI GEDAQVLKDL ESRIAKALPN VDRYDIVSKS IANQHYLIHA 

       310        320        330        340        350        360 
SNFDEACHVM NTIAPEHASI QTVNPQPYIE KVKYVGALFI GHYSPEVIGD YVAGPSHVLP 

       370        380        390        400        410 
TNRTARFTNG LSVNDFLTRN TVIHLSKDTF EQIADSAQHI AHVEALYNHQ QSILIRQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571857 Genomic DNA. Translation: CAG44380.1.
RefSeqYP_044677.1. NC_002953.3.

3D structure databases

ProteinModelPortalQ6G5Z7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING282459.SAS2563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2863710.
KEGGsas:SAS2563.
PATRIC19554802. VBIStaAur96780_2670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAYAAKLCG.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_STAAS
AccessionPrimary (citable) accession number: Q6G5Z7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways