UniProtKB - Q6G5W5 (MNMG_STAAS)
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Protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Gene
mnmG
Organism
Staphylococcus aureus (strain MSSA476)
Status
Functioni
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation
Cofactori
FADUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 123 | FAD; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 178 | FADUniRule annotation | 1 | |
Binding sitei | 367 | FADUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 11 – 16 | FADUniRule annotation | 6 | |
Nucleotide bindingi | 270 – 284 | NADUniRule annotationAdd BLAST | 15 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
GO - Biological processi
- tRNA wobble uridine modification Source: InterPro
Keywordsi
Biological process | tRNA processing |
Ligand | FAD, Flavoprotein, NAD |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotationAlternative name(s): Glucose-inhibited division protein AUniRule annotation |
Gene namesi | Name:mnmGUniRule annotation Synonyms:gidAUniRule annotation Ordered Locus Names:SAS2593 |
Organismi | Staphylococcus aureus (strain MSSA476) |
Taxonomic identifieri | 282459 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000117177 | 1 – 625 | tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGAdd BLAST | 625 |
Proteomic databases
PRIDEi | Q6G5W5 |
Interactioni
Subunit structurei
Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | Q6G5W5 |
SMRi | Q6G5W5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the MnmG family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000201059 |
KOi | K03495 |
OMAi | FRPGYAI |
Family and domain databases
Gene3Di | 3.50.50.602 hits |
HAMAPi | MF_00129 MnmG_GidA, 1 hit |
InterProi | View protein in InterPro IPR036188 FAD/NAD-bd_sf IPR026904 GidA-assoc_3 IPR004416 MnmG IPR002218 MnmG-rel IPR020595 MnmG-rel_CS |
PANTHERi | PTHR11806 PTHR11806, 1 hit PTHR11806:SF0 PTHR11806:SF0, 1 hit |
Pfami | View protein in Pfam PF01134 GIDA, 1 hit PF13932 GIDA_assoc, 1 hit |
SUPFAMi | SSF51905 SSF51905, 2 hits |
TIGRFAMsi | TIGR00136 gidA, 1 hit |
PROSITEi | View protein in PROSITE PS01280 GIDA_1, 1 hit PS01281 GIDA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6G5W5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQEYDVIVI GAGHAGVEAG LASARRGAKT LMLTINLDNI AFMPCNPSVG
60 70 80 90 100
GPAKGIVVRE IDALGGQMAK TIDKTHIQMR MLNTGKGPAV RALRAQADKV
110 120 130 140 150
LYQQEMKRVI EDEENLHIMQ GMVDELIIED NEVKGVRTNI GTEYLSKAVI
160 170 180 190 200
ITTGTFLRGE IILGNMKYSS GPNHQLPSIT LSDNLRELGF DIVRFKTGTP
210 220 230 240 250
PRVNSKTIDY SKTEIQPGDD VGRAFSFETT EYILDQLPCW LTYTNAETHK
260 270 280 290 300
VIDDNLHLSA MYSGMIKGTG PRYCPSIEDK FVRFNDKPRH QLFLEPEGRN
310 320 330 340 350
TNEVYVQGLS TSLPEHVQRQ MLETIPGLEK ADMMRAGYAI EYDAIVPTQL
360 370 380 390 400
WPTLETKMIK NLYTAGQING TSGYEEAAGQ GLMAGINAAG KVLNTGEKIL
410 420 430 440 450
SRSDAYIGVL IDDLVTKGTN EPYRLLTSRA EYRLLLRHDN ADLRLTDMGY
460 470 480 490 500
ELGMISEERY ARFNEKRQQI DAEIKRLSDI RIKPNEHTQA IIEQHGGSRL
510 520 530 540 550
KDGILAIDLL RRPEMTYDII LEILEEEHQL NADVEEQVEI QTKYEGYINK
560 570 580 590 600
SLQQVEKVKR MEEKKIPEDL DYSKIDSLAT EAREKLSEVK PLNIAQASRI
610 620
SGVNPADISI LLIYLEQGKL QRVSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571857 Genomic DNA Translation: CAG44412.1 |
RefSeqi | WP_000249657.1, NC_002953.3 |
Genome annotation databases
KEGGi | sas:SAS2593 |
Similar proteinsi
Entry informationi
Entry namei | MNMG_STAAS | |
Accessioni | Q6G5W5Primary (citable) accession number: Q6G5W5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | March 28, 2018 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |