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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei178FADUniRule annotation1
Binding sitei367FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16FADUniRule annotation6
Nucleotide bindingi270 – 284NADUniRule annotationAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:SAS2593
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001171771 – 625tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGAdd BLAST625

Proteomic databases

PRIDEiQ6G5W5.

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6G5W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000201059.
KOiK03495.
OMAiFRPGYAI.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6G5W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQEYDVIVI GAGHAGVEAG LASARRGAKT LMLTINLDNI AFMPCNPSVG
60 70 80 90 100
GPAKGIVVRE IDALGGQMAK TIDKTHIQMR MLNTGKGPAV RALRAQADKV
110 120 130 140 150
LYQQEMKRVI EDEENLHIMQ GMVDELIIED NEVKGVRTNI GTEYLSKAVI
160 170 180 190 200
ITTGTFLRGE IILGNMKYSS GPNHQLPSIT LSDNLRELGF DIVRFKTGTP
210 220 230 240 250
PRVNSKTIDY SKTEIQPGDD VGRAFSFETT EYILDQLPCW LTYTNAETHK
260 270 280 290 300
VIDDNLHLSA MYSGMIKGTG PRYCPSIEDK FVRFNDKPRH QLFLEPEGRN
310 320 330 340 350
TNEVYVQGLS TSLPEHVQRQ MLETIPGLEK ADMMRAGYAI EYDAIVPTQL
360 370 380 390 400
WPTLETKMIK NLYTAGQING TSGYEEAAGQ GLMAGINAAG KVLNTGEKIL
410 420 430 440 450
SRSDAYIGVL IDDLVTKGTN EPYRLLTSRA EYRLLLRHDN ADLRLTDMGY
460 470 480 490 500
ELGMISEERY ARFNEKRQQI DAEIKRLSDI RIKPNEHTQA IIEQHGGSRL
510 520 530 540 550
KDGILAIDLL RRPEMTYDII LEILEEEHQL NADVEEQVEI QTKYEGYINK
560 570 580 590 600
SLQQVEKVKR MEEKKIPEDL DYSKIDSLAT EAREKLSEVK PLNIAQASRI
610 620
SGVNPADISI LLIYLEQGKL QRVSD
Length:625
Mass (Da):70,116
Last modified:July 19, 2004 - v1
Checksum:i62DE2C9CA0889CD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG44412.1.
RefSeqiWP_000249657.1. NC_002953.3.

Genome annotation databases

KEGGisas:SAS2593.
PATRICi19554864. VBIStaAur96780_2701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA. Translation: CAG44412.1.
RefSeqiWP_000249657.1. NC_002953.3.

3D structure databases

ProteinModelPortaliQ6G5W5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6G5W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisas:SAS2593.
PATRICi19554864. VBIStaAur96780_2701.

Phylogenomic databases

HOGENOMiHOG000201059.
KOiK03495.
OMAiFRPGYAI.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNMG_STAAS
AccessioniPrimary (citable) accession number: Q6G5W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: October 5, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.