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Q6G5S5

- PUR9_BARHE

UniProt

Q6G5S5 - PUR9_BARHE

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, BH15970
Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1592-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:BH15970
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018845Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH15970.

Structurei

3D structure databases

ProteinModelPortaliQ6G5S5.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G5S5-1 [UniParc]FASTAAdd to Basket

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MGVVAKNFPI PDLHRVRRVL LSVSDKTGIV AFAQALQTYN VELISTGGTA    50
KVLMAAGLPV RDVAEVTGFP EIMDGRVKTL HPLIHGALLG VREDPSHAVA 100
MEQYGIHGID LLVVNLYPFE ETVQSGADGQ TILENIDIGG PAMIRAAAKN 150
HVYTGVITAV SDYDAVLSEL KQHDGCLSFS MRQQLAMRAY AHTAAYDTAI 200
AAWFAKNLKI ETPSWQSFSG HLKNVMRYGE NPHQKAAFYR NGDKRFGVAT 250
AKLLQGKALS YNNMNDTDAA FELVAEFDPQ NTAAVALIKH ANPCGVAEGQ 300
TLKEAYLKAL LCDNVSAFGG IIALNQPLDA ECAEEVIKIF TEVIIAPDAT 350
MEAREIISGK KNLRLLLTGG VPDPRCGGFI AKTLAGGILV QSRDNVVVDD 400
LKLQVVTKRA PSQEEMRDLQ FAFRVVKHVK SNAIVYAKNS ATVGIGAGQM 450
SRVDSAKIAA RKAEESAKRA GLTESLTKGS VVASDAFFPF ADGLLAVAEA 500
GATAVIQPGG SMRDEEVIAA ADAQGLAMVF TGVRHFRH 538
Length:538
Mass (Da):57,597
Last modified:July 19, 2004 - v1
Checksum:i297641A8121EB54F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF28360.1.
RefSeqiWP_011181360.1. NC_005956.1.
YP_034290.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF28360; CAF28360; BH15970.
GeneIDi2864772.
KEGGibhe:BH15970.
PATRICi20547496. VBIBarHen29080_1856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF28360.1 .
RefSeqi WP_011181360.1. NC_005956.1.
YP_034290.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G5S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH15970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF28360 ; CAF28360 ; BH15970 .
GeneIDi 2864772.
KEGGi bhe:BH15970.
PATRICi 20547496. VBIBarHen29080_1856.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BHEN283166:GIVZ-1592-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiPUR9_BARHE
AccessioniPrimary (citable) accession number: Q6G5S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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