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Q6G5R9

- PUR5_BARHE

UniProt

Q6G5R9 - PUR5_BARHE

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-954-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:BH09560
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH09560.

Structurei

3D structure databases

ProteinModelPortaliQ6G5R9.
SMRiQ6G5R9. Positions 14-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G5R9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQDLINDK SKNGLTYAKA GVNIDMGNAM VEKIKPFIRA TKRAGTDAEI
60 70 80 90 100
GGFGGLFDLK AAGFTDPILV AANDGVGTKL KIAIEVGIHD TIGIDLVAMC
110 120 130 140 150
VNDLLVQGAE PLFFLDYFAT GKLDPEQGAA IVSGIAKGCQ QAGAALIGGE
160 170 180 190 200
TAEMPDMYAK GDYDLAGFAV GAAERSALLP SKDLTEGDII LGLSSSGIHS
210 220 230 240 250
NGFSLVRRII QQSDLKWNDH APFNPQMNLG TALLTPTRIY VKSLLPIIKS
260 270 280 290 300
YKGIKALAHI TGGGFLENIP RVLPSSLCAE INLSAIHVPS IFSWIAKQGK
310 320 330 340 350
IEKIEMLRTF NCGVGMIIIV AQHEVEKVTQ ELKMQGETVT LLGKLTKRQN
360
KGITFKGALH L
Length:361
Mass (Da):38,503
Last modified:July 19, 2004 - v1
Checksum:iEAFFE6943B86426B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27749.1.
RefSeqiYP_033751.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF27749; CAF27749; BH09560.
GeneIDi2864775.
KEGGibhe:BH09560.
PATRICi20545727. VBIBarHen29080_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27749.1 .
RefSeqi YP_033751.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G5R9.
SMRi Q6G5R9. Positions 14-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH09560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF27749 ; CAF27749 ; BH09560 .
GeneIDi 2864775.
KEGGi bhe:BH09560.
PATRICi 20545727. VBIBarHen29080_1000.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci BHEN283166:GIVZ-954-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiPUR5_BARHE
AccessioniPrimary (citable) accession number: Q6G5R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3