Q6G5K3 (UBIG_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-demethylubiquinone-9 3-methyltransferase
EC=2.1.1.64

Alternative name(s):
2-polyprenyl-6-hydroxyphenyl methylase
EC=2.1.1.222
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
Short name=DHHB methyltransferase

Gene names

Name:	ubiG
Ordered Locus Names:	BH04020

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Non-specific O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway By similarity.
Catalytic activity	S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. HAMAP MF_00472 S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_00472
Sequence similarities	Belongs to the methyltransferase superfamily. UbiG/COQ3 family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Inferred from electronic annotation. Source: InterPro 3-demethylubiquinone-9 3-O-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	3-demethylubiquinone-9 3-methyltransferase HAMAP MF_00472		PRO_0000193366

Sequences

	Sequence		Length	Mass (Da)
	Q6G5K3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: E135826B535ACE3B	FASTA	247	27,985
	10 20 30 40 50 60 MINETRTTLD QSEVDHFSRI AAEWWNPHGK FRPLHQFNPT RLAYIREKIC LELHRDPVSL 70 80 90 100 110 120 KPFENLKILD IGCGGGLLCE PMARLGAMVV GADASQTNIE VAKIHAAQNG LSIDYRTTTA 130 140 150 160 170 180 EALATEGEQF DIILNMEVVE HVADVNLFIE ATAKMLKPQG LMFISTLNRT WKAWGLAIIG 190 200 210 220 230 240 AEYILRWLPK GTHNYKKFLK PRELKNLLLQ NALTVVDEIG VTYNPLNDSW NRSKDMNVNY LLLAKKS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27211.1.
RefSeq	YP_033242.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q6G5K3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2864849.
GenomeReviews	Gene locus BH04020 in contig BX897699_GR.
KEGG	bhe:BH04020.
NMPDR	fig|283166.1.peg.370.
PATRIC	20544563. VBIBarHen29080_0435.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG738842.
OMA	KFITPDE.
PhylomeDB	Q6G5K3.
ProtClustDB	PRK05134.
Enzyme and pathway databases
BioCyc	BHEN283166:BH04020-MONOMER.
Family and domain databases
HAMAP	MF_00472. UbiG. [Tree]
InterPro	IPR013216. Methyltransf_11. IPR010233. UbiG_MeTrfase. [Graphical view]
KO	K00568.
PANTHER	PTHR23134. PTHR23134. 1 hit.
Pfam	PF08241. Methyltransf_11. 1 hit. [Graphical view]
TIGRFAMs	TIGR01983. UbiG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UBIG_BARHE

Accession

Primary (citable) accession number: Q6G5K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program