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Q6G5H6

- PNCB_BARHE

UniProt

Q6G5H6 - PNCB_BARHE

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-91-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BH00910
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146829Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH00910.

Structurei

3D structure databases

ProteinModelPortaliQ6G5H6.
SMRiQ6G5H6. Positions 1-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G5H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHPDIARRV YNHTWKLDPI IRSLLDTDFY KLLMVQMIWG LYPNVNVTFS
60 70 80 90 100
LINRSKTIRL ADDIDEMELR AQLDHALNLR FTKKEMIWLA GNTFYGRKQI
110 120 130 140 150
FEPDFLQWLE NFQLPEYELT RKDGQYILHF HGPWTHSSMW EIPALSIISE
160 170 180 190 200
LRSRAAMKKL DRFTLDVLYA RAKAKMWSKV ERLKKLPNIK ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGNSF TGTSNVLLAM DTDLEALGTN AHELPMVIAA
260 270 280 290 300
LTNNDNELRK APYQVLQDWN RYYGGNLLIV LPDTFGTEAF LRNAPDWVAD
310 320 330 340 350
WTGFRPDSAP PLEGGERIIQ WWREKGKDPR EKLLIFSDAL DIDTIEKTYH
360 370 380 390 400
HFHGKVRMSF GWGTDLTNDF VGCSPQETAT FDALSLVCKV THANGRPAVK
410 420 430
LSDNPEKTIG NPQEIQRYLN FFGNENRVAK PIKT
Length:434
Mass (Da):50,421
Last modified:July 19, 2004 - v1
Checksum:iA6BBDEB1EA5FDB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA. Translation: CAF26907.1.
RefSeqiYP_032954.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF26907; CAF26907; BH00910.
GeneIDi2865455.
KEGGibhe:BH00910.
PATRICi20543893. VBIBarHen29080_0107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA. Translation: CAF26907.1 .
RefSeqi YP_032954.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G5H6.
SMRi Q6G5H6. Positions 1-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH00910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF26907 ; CAF26907 ; BH00910 .
GeneIDi 2865455.
KEGGi bhe:BH00910.
PATRICi 20543893. VBIBarHen29080_0107.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BHEN283166:GIVZ-91-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiPNCB_BARHE
AccessioniPrimary (citable) accession number: Q6G5H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3