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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathway: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-91-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BH00910
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146829Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH00910.

Structurei

3D structure databases

ProteinModelPortaliQ6G5H6.
SMRiQ6G5H6. Positions 1-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G5H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHPDIARRV YNHTWKLDPI IRSLLDTDFY KLLMVQMIWG LYPNVNVTFS
60 70 80 90 100
LINRSKTIRL ADDIDEMELR AQLDHALNLR FTKKEMIWLA GNTFYGRKQI
110 120 130 140 150
FEPDFLQWLE NFQLPEYELT RKDGQYILHF HGPWTHSSMW EIPALSIISE
160 170 180 190 200
LRSRAAMKKL DRFTLDVLYA RAKAKMWSKV ERLKKLPNIK ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGNSF TGTSNVLLAM DTDLEALGTN AHELPMVIAA
260 270 280 290 300
LTNNDNELRK APYQVLQDWN RYYGGNLLIV LPDTFGTEAF LRNAPDWVAD
310 320 330 340 350
WTGFRPDSAP PLEGGERIIQ WWREKGKDPR EKLLIFSDAL DIDTIEKTYH
360 370 380 390 400
HFHGKVRMSF GWGTDLTNDF VGCSPQETAT FDALSLVCKV THANGRPAVK
410 420 430
LSDNPEKTIG NPQEIQRYLN FFGNENRVAK PIKT
Length:434
Mass (Da):50,421
Last modified:July 19, 2004 - v1
Checksum:iA6BBDEB1EA5FDB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA. Translation: CAF26907.1.
RefSeqiWP_011180052.1. NC_005956.1.
YP_032954.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF26907; CAF26907; BH00910.
KEGGibhe:BH00910.
PATRICi20543893. VBIBarHen29080_0107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA. Translation: CAF26907.1.
RefSeqiWP_011180052.1. NC_005956.1.
YP_032954.1. NC_005956.1.

3D structure databases

ProteinModelPortaliQ6G5H6.
SMRiQ6G5H6. Positions 1-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283166.BH00910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26907; CAF26907; BH00910.
KEGGibhe:BH00910.
PATRICi20543893. VBIBarHen29080_0107.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiKLTMQCA.
OrthoDBiEOG6X10XB.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciBHEN283166:GIVZ-91-MONOMER.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiPNCB_BARHE
AccessioniPrimary (citable) accession number: Q6G5H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 19, 2004
Last modified: June 24, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.