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Q6G5H6

- PNCB_BARHE

UniProt

Q6G5H6 - PNCB_BARHE

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, BH00910
Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-91-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:BH00910
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferaseUniRule annotationPRO_1000146829Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH00910.

Structurei

3D structure databases

ProteinModelPortaliQ6G5H6.
SMRiQ6G5H6. Positions 1-426.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G5H6-1 [UniParc]FASTAAdd to Basket

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MNHPDIARRV YNHTWKLDPI IRSLLDTDFY KLLMVQMIWG LYPNVNVTFS    50
LINRSKTIRL ADDIDEMELR AQLDHALNLR FTKKEMIWLA GNTFYGRKQI 100
FEPDFLQWLE NFQLPEYELT RKDGQYILHF HGPWTHSSMW EIPALSIISE 150
LRSRAAMKKL DRFTLDVLYA RAKAKMWSKV ERLKKLPNIK ISDFGTRRRH 200
SFLWQRWCVE ALKEGIGNSF TGTSNVLLAM DTDLEALGTN AHELPMVIAA 250
LTNNDNELRK APYQVLQDWN RYYGGNLLIV LPDTFGTEAF LRNAPDWVAD 300
WTGFRPDSAP PLEGGERIIQ WWREKGKDPR EKLLIFSDAL DIDTIEKTYH 350
HFHGKVRMSF GWGTDLTNDF VGCSPQETAT FDALSLVCKV THANGRPAVK 400
LSDNPEKTIG NPQEIQRYLN FFGNENRVAK PIKT 434
Length:434
Mass (Da):50,421
Last modified:July 19, 2004 - v1
Checksum:iA6BBDEB1EA5FDB13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF26907.1.
RefSeqiWP_011180052.1. NC_005956.1.
YP_032954.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF26907; CAF26907; BH00910.
GeneIDi2865455.
KEGGibhe:BH00910.
PATRICi20543893. VBIBarHen29080_0107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF26907.1 .
RefSeqi WP_011180052.1. NC_005956.1.
YP_032954.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G5H6.
SMRi Q6G5H6. Positions 1-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH00910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF26907 ; CAF26907 ; BH00910 .
GeneIDi 2865455.
KEGGi bhe:BH00910.
PATRICi 20543893. VBIBarHen29080_0107.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BHEN283166:GIVZ-91-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiPNCB_BARHE
AccessioniPrimary (citable) accession number: Q6G5H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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