Reviewed, UniProtKB/Swiss-Prot Q6G5G6 (PSD_BARHE)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Synonyms:	psdA
Ordered Locus Names:	BH05210

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029753
	Chain	190 – 232	43	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029754
Sites
	Site	189 – 190	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	190	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G5G6-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: A9A0E4E584E3BB42	FASTA	232	25,948
	10 20 30 40 50 60 MSILQSVHNS FAPIHKEGYP FIIAFFVISL ILGWVWSPLF WCGLVLTVWC IYFFRDPERV 70 80 90 100 110 120 IPLNPNWIIS PADGRISFVG PCIPPEELGL GNAEMIRISV FMDIFSCHIN RVPISGKVES 130 140 150 160 170 180 IIYHPGQFAN AELDKASQFN ERNGVVIDSK HGKIGVVQIA GAIARRIVCW SQEDDSVVTG 190 200 210 220 230 QRFGLIRFGS RLDIYIPNEV KLRVTVGQTS IAGETVLGSF DDKSATTEFR FD

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27329.1.
RefSeq	YP_033357.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2865535.
GenomeReviews	Gene locus BH05210 in contig BX897699_GR.
KEGG	bhe:BH05210.
NMPDR	fig|283166.1.peg.485.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG541103.
OMA	IFMSVFN.
Enzyme and pathway databases
BioCyc	BHEN283166:BH05210-MONOMER.
BRENDA	4.1.1.65. 277357.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BARHE

Accession

Primary (citable) accession number: Q6G5G6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)