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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi488MagnesiumUniRule annotation1
Metal bindingi494MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciBHEN283166:G1GJ7-216-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:BH02100
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295271 – 733Polyribonucleotide nucleotidyltransferaseAdd BLAST733

Proteomic databases

PaxDbiQ6G5F8
PRIDEiQ6G5F8

Interactioni

Protein-protein interaction databases

STRINGi283166.BH02100

Structurei

3D structure databases

ProteinModelPortaliQ6G5F8
SMRiQ6G5F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini555 – 614KHUniRule annotationAdd BLAST60
Domaini624 – 692S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G5F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKTHKIEIE WAGRPLTLET GKIARQADGA VIATYGETIV LATVVSAKSP
60 70 80 90 100
KPDQDFFPLT VNYQEKSYAV GRIPGGYLKR ESRPSENETL ISRLIDRPIR
110 120 130 140 150
PLFADGYKND TQVIVSVIQH DLENNPDILA MIASSAALTL SGVPFMGPIA
160 170 180 190 200
GARVGYCNGQ YILNPHIDEM SESKLDLVVA GTENAVLMVE SEAQELPEDI
210 220 230 240 250
MLGAVMFGHK GLQPILDAII KLAEVAAKDP RDFVPEDLSD LETAMLEMAE
260 270 280 290 300
KDIRKAYTIT DKQERYAALD ALKTEIINKF MPETEEDCKF SVDQIATVFK
310 320 330 340 350
QLQAKIVRSN ILDTKKRIDG RDLSTVRPIQ SEVGILPRTH GSALFTRGET
360 370 380 390 400
QAIVVATLGT GEDEQYIDSL TGMYKETFLL HYNFPPFSVG ETGRLGSPGR
410 420 430 440 450
REIGHGKLAW RAIHPMLPSK ESFPYTIRAV SEITESNGSS SMATVCGTSL
460 470 480 490 500
ALMDAGVPLA RPVAGIAMGL IKEGERFAVL SDILGDEDHL GDMDFKVAGT
510 520 530 540 550
ANGITALQMD IKIDGITEEI MKIALEQAKG GRIHILNEMA KALTSARAEL
560 570 580 590 600
SEFSPRIEVM NIAVDKIRDV IGTGGKVIRE IVEQTGAKIN IEDDGTIRIA
610 620 630 640 650
SADAKTIEAA KRWIHSIVDE PEVGVIYQGT VVKTAEFGAF VNFFGSRDGL
660 670 680 690 700
VHISQLTTER VTKTTDVVKE GDKVWVKLMG FDERGKVRLS MKIVDQKTGK
710 720 730
EIIGEDSIKA EQEKYTEETH KSENKRRRKK KEE
Length:733
Mass (Da):80,652
Last modified:July 19, 2004 - v1
Checksum:i406465FF5C0220DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF27022.1
RefSeqiWP_011180161.1, NZ_LRIJ02000001.1

Genome annotation databases

EnsemblBacteriaiCAF27022; CAF27022; BH02100
GeneIDi29620880
KEGGibhe:BH02100

Similar proteinsi

Entry informationi

Entry nameiPNP_BARHE
AccessioniPrimary (citable) accession number: Q6G5F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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