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Q6G5F8

- PNP_BARHE

UniProt

Q6G5F8 - PNP_BARHE

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:BH02100
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Polyribonucleotide nucleotidyltransferasePRO_0000329527Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH02100.

Structurei

3D structure databases

ProteinModelPortaliQ6G5F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6G5F8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKTHKIEIE WAGRPLTLET GKIARQADGA VIATYGETIV LATVVSAKSP
60 70 80 90 100
KPDQDFFPLT VNYQEKSYAV GRIPGGYLKR ESRPSENETL ISRLIDRPIR
110 120 130 140 150
PLFADGYKND TQVIVSVIQH DLENNPDILA MIASSAALTL SGVPFMGPIA
160 170 180 190 200
GARVGYCNGQ YILNPHIDEM SESKLDLVVA GTENAVLMVE SEAQELPEDI
210 220 230 240 250
MLGAVMFGHK GLQPILDAII KLAEVAAKDP RDFVPEDLSD LETAMLEMAE
260 270 280 290 300
KDIRKAYTIT DKQERYAALD ALKTEIINKF MPETEEDCKF SVDQIATVFK
310 320 330 340 350
QLQAKIVRSN ILDTKKRIDG RDLSTVRPIQ SEVGILPRTH GSALFTRGET
360 370 380 390 400
QAIVVATLGT GEDEQYIDSL TGMYKETFLL HYNFPPFSVG ETGRLGSPGR
410 420 430 440 450
REIGHGKLAW RAIHPMLPSK ESFPYTIRAV SEITESNGSS SMATVCGTSL
460 470 480 490 500
ALMDAGVPLA RPVAGIAMGL IKEGERFAVL SDILGDEDHL GDMDFKVAGT
510 520 530 540 550
ANGITALQMD IKIDGITEEI MKIALEQAKG GRIHILNEMA KALTSARAEL
560 570 580 590 600
SEFSPRIEVM NIAVDKIRDV IGTGGKVIRE IVEQTGAKIN IEDDGTIRIA
610 620 630 640 650
SADAKTIEAA KRWIHSIVDE PEVGVIYQGT VVKTAEFGAF VNFFGSRDGL
660 670 680 690 700
VHISQLTTER VTKTTDVVKE GDKVWVKLMG FDERGKVRLS MKIVDQKTGK
710 720 730
EIIGEDSIKA EQEKYTEETH KSENKRRRKK KEE
Length:733
Mass (Da):80,652
Last modified:July 19, 2004 - v1
Checksum:i406465FF5C0220DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27022.1.
RefSeqiWP_011180161.1. NC_005956.1.
YP_033063.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF27022; CAF27022; BH02100.
GeneIDi2865516.
KEGGibhe:BH02100.
PATRICi20544165. VBIBarHen29080_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27022.1 .
RefSeqi WP_011180161.1. NC_005956.1.
YP_033063.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G5F8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH02100.

Protocols and materials databases

DNASUi 2865516.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF27022 ; CAF27022 ; BH02100 .
GeneIDi 2865516.
KEGGi bhe:BH02100.
PATRICi 20544165. VBIBarHen29080_0239.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BHEN283166:GIVZ-210-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiPNP_BARHE
AccessioniPrimary (citable) accession number: Q6G5F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3