ID   AROE_BARHE              Reviewed;         293 AA.
AC   Q6G5A9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BH00030;
OS   Bartonella henselae (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=38323;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic
RT   derivative of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; BX897699; CAF26819.1; -; Genomic_DNA.
DR   RefSeq; YP_032875.1; -.
DR   GeneID; 2866080; -.
DR   GenomeReviews; BX897699_GR; BH00030.
DR   KEGG; bhe:BH00030; -.
DR   NMPDR; fig|283166.1.peg.3; -.
DR   HOGENOM; Q6G5A9; -.
DR   OMA; Q6G5A9; AYGFSAN.
DR   BioCyc; BHEN283166:BH00030-MON; -.
DR   BRENDA; 1.1.1.25; 277357.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    293       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325103.
FT   NP_BIND     137    141       NADP (By similarity).
FT   ACT_SITE     77     77       Proton acceptor (Potential).
SQ   SEQUENCE   293 AA;  33007 MW;  D3C00D1C8EAC4D24 CRC64;
     MVNLTIKREK KKIPRAFVVG TPIHHSKSPK IHNFWLKQYD LQGEYLAQEV TSEEFRDFLT
     SLKRRGFCGG NVTLPHKQEA FHLANYKDDV ATMIGAVNTL WYEGDKLCGT NSDAYGFSAN
     LDDSAPDWMG ETALVFGAGG AARAILYALK KRGFERICLV NRTKQRAESL AEHFGKPVEV
     CDWYKAHEIL YQADLIVNTT SVGMINSNEK ESTSFFCDFH KTKTTALVTD IVYTPLVTPF
     LQRAKAHGLR TVDGLGMLLH QAVLGFERWF GIRPRVTKAL RATILQDMGE KRG
//