Reviewed, UniProtKB/Swiss-Prot Q6G5A9 (AROE_BARHE)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BH00030

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325103
Regions
	Nucleotide binding	137 – 141	5	NADP By similarity
Sites
	Active site	77	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6G5A9-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: D3C00D1C8EAC4D24	FASTA	293	33,007
	10 20 30 40 50 60 MVNLTIKREK KKIPRAFVVG TPIHHSKSPK IHNFWLKQYD LQGEYLAQEV TSEEFRDFLT 70 80 90 100 110 120 SLKRRGFCGG NVTLPHKQEA FHLANYKDDV ATMIGAVNTL WYEGDKLCGT NSDAYGFSAN 130 140 150 160 170 180 LDDSAPDWMG ETALVFGAGG AARAILYALK KRGFERICLV NRTKQRAESL AEHFGKPVEV 190 200 210 220 230 240 CDWYKAHEIL YQADLIVNTT SVGMINSNEK ESTSFFCDFH KTKTTALVTD IVYTPLVTPF 250 260 270 280 290 LQRAKAHGLR TVDGLGMLLH QAVLGFERWF GIRPRVTKAL RATILQDMGE KRG

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF26819.1.
RefSeq	YP_032875.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866080.
GenomeReviews	Gene locus BH00030 in contig BX897699_GR.
KEGG	bhe:BH00030.
NMPDR	fig|283166.1.peg.3.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G5A9.
OMA	AYGFSAN.
Enzyme and pathway databases
BioCyc	BHEN283166:BH00030-MON.
BRENDA	1.1.1.25. 277357.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BARHE

Accession

Primary (citable) accession number: Q6G5A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)