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Q6G5A9 (AROE_BARHE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:BH00030
OrganismBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]
Taxonomic identifier283166 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Shikimate dehydrogenase HAMAP MF_00222
PRO_0000325103

Regions

Nucleotide binding137 – 1415NADP By similarity

Sites

Active site771Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
Q6G5A9 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: D3C00D1C8EAC4D24

FASTA29333,007
        10         20         30         40         50         60 
MVNLTIKREK KKIPRAFVVG TPIHHSKSPK IHNFWLKQYD LQGEYLAQEV TSEEFRDFLT 

        70         80         90        100        110        120 
SLKRRGFCGG NVTLPHKQEA FHLANYKDDV ATMIGAVNTL WYEGDKLCGT NSDAYGFSAN 

       130        140        150        160        170        180 
LDDSAPDWMG ETALVFGAGG AARAILYALK KRGFERICLV NRTKQRAESL AEHFGKPVEV 

       190        200        210        220        230        240 
CDWYKAHEIL YQADLIVNTT SVGMINSNEK ESTSFFCDFH KTKTTALVTD IVYTPLVTPF 

       250        260        270        280        290 
LQRAKAHGLR TVDGLGMLLH QAVLGFERWF GIRPRVTKAL RATILQDMGE KRG

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX897699 Genomic DNA. Translation: CAF26819.1.
RefSeqYP_032875.1. NC_005956.1.

3D structure databases

HSSPHSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
ProteinModelPortalQ6G5A9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2866080.
GenomeReviewsGene locus BH00030 in contig BX897699_GR.
KEGGbhe:BH00030.
NMPDRfig|283166.1.peg.3.
PATRIC20543685. VBIBarHen29080_0003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG553408.
OMAFERWFGI.
PhylomeDBQ6G5A9.
ProtClustDBPRK00258.

Enzyme and pathway databases

BioCycBHEN283166:BH00030-MONOMER.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_BARHE
AccessionPrimary (citable) accession number: Q6G5A9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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