Reviewed, UniProtKB/Swiss-Prot Q6G584 (SAHH_BARHE)

Names and origin

Protein names

Recommended name:
    Adenosylhomocysteinase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
      Short name=AdoHcyase

Gene names

Name:	ahcY
Ordered Locus Names:	BH00310

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563
Cofactor	Binds 1 NAD per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Adenosylhomocysteinase HAMAP MF_00563		PRO_0000116944
Regions
	Region	218 – 383	166	NAD binding By similarity
Sites
	Binding site	56	1	Substrate By similarity
	Binding site	131	1	Substrate By similarity
	Binding site	191	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity
	Binding site	225	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G584-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 45F2E7583A655434	FASTA	465	51,029
	10 20 30 40 50 60 MTAQDYVVKD IALAAYGRKE LDIAETEMPG LMACREEFSS SQPLRGARIS GSLHMTIQTA 70 80 90 100 110 120 VLIETLKAIG ANVRWSSSNI FSTQDHAAAA IAATGTPVFA VKGETLEEYW TYIDAIFQWP 130 140 150 160 170 180 DGNPSNLILD DGADATNYIL MGSRAETNKD ILSHPKTEEE ELFFKQIQRR MEATPGFFTR 190 200 210 220 230 240 QRAAIKGISE ETTTGVHRLH QLQKEGLLPF PAININDSVT KSKFDNKYGC RESLVDGIRR 250 260 270 280 290 300 ATDVMIAGKT AIVCGYGDVG KGSAASLSGA GARVKVTEID PICALQAAMD GYEVVNLDDA 310 320 330 340 350 360 ASSADIIITT TGNKDIVRLD HMRKVKDMCI LGNIGHFDNE IQVAALQNLP WTNIKPQVDM 370 380 390 400 410 420 ITFPDGKRII LLSEGRLLNL GNATGHPSFV MSASFTNQVL AQIELFTRSG HYKNEVTVLP 430 440 450 460 KYLDEKVARL HLDQLGIKLT TLSQEQAAYI GVTPQGPYKP DHYRY

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF26847.1.
RefSeq	YP_032900.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866066.
GenomeReviews	Gene locus BH00310 in contig BX897699_GR.
KEGG	bhe:BH00310.
NMPDR	fig|283166.1.peg.28.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G584.
OMA	HMRAMKD.
Enzyme and pathway databases
BioCyc	BHEN283166:BH00310-MON.
BRENDA	3.3.1.1. 277357.
Family and domain databases
HAMAP	MF_00563. [Tree]
InterPro	IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR000043. S-Ado-L-homoCys_hydrolase. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMs	TIGR00936. ahcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH_BARHE

Accession

Primary (citable) accession number: Q6G584

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)