Reviewed, UniProtKB/Swiss-Prot Q6G565 (NTPA_BARHE)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BH00540

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Nucleoside-triphosphatase		PRO_0000178131

Sequences

	Sequence		Length	Mass (Da)
	Q6G565-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 81412B2F37053261	FASTA	215	23,662
	10 20 30 40 50 60 MRSIANKKLV IATHNIGKLQ EITTLVAPFG LTIQSAKELG LPEPKETGTT FEENAYIKAF 70 80 90 100 110 120 AAAKNTGLPA LSDDSGLEVD ALNGAPGVYT ADLALQSDGT RDFLKAMQKI EEKLQKIGAH 130 140 150 160 170 180 KKSQRKCRFI SVICIAWPDA HADYFHGRVE GSFIWPPRGD KGFGFDPVFL PDGYKNTFGE 190 200 210 MTTEQKHGWK LNDQTPLSHR ACAFKLLAEN LLKLS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF26870.1.
RefSeq	YP_032919.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2865975.
GenomeReviews	Gene locus BH00540 in contig BX897699_GR.
KEGG	bhe:BH00540.
NMPDR	fig|283166.1.peg.47.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G565.
Enzyme and pathway databases
BioCyc	BHEN283166:BH00540-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_BARHE

Accession

Primary (citable) accession number: Q6G565

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 19, 2004
Last modified:	July 22, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)