Q6G552 (ARGB_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	BH00690

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112589
Regions
	Region	72 – 73	2	Substrate binding By similarity
Sites
	Binding site	94	1	Substrate By similarity
	Binding site	199	1	Substrate By similarity
	Site	37	1	Transition state stabilizer By similarity
	Site	259	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G552 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 20ED1885C3BEC5A4	FASTA	301	32,256
	10 20 30 40 50 60 MDDVENGVAD VFEKQAAFLS SALPYMQKYE NETVVVKYGG HAMGDPALGR AFARDIALLK 70 80 90 100 110 120 QSGINPVVVH GGGPQIAEIL MKMGIESRFE NGLRVTDERI VEVVEMVLAG SINKEIVALI 130 140 150 160 170 180 NAEGEWAIGL CGKDGNMVFA EKAYKTVIDP DSHIERVLDL GFVGEPVEVD RTLLDLLACS 190 200 210 220 230 240 EMIPVLAPVA PGRDGKTYNI NADIFAGAIA GALEAKRLLF LTDVPGVLDK KGKLLKELTI 250 260 270 280 290 300 SEAENLIKNE TISGGMIPKV ETCMKALQNG VEAVVILNGR TPHSVLLELF TEQGAGTLIV S

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF26885.1.
RefSeq	YP_032932.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q6G552.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2866072.
GenomeReviews	Gene locus BH00690 in contig BX897699_GR.
KEGG	bhe:BH00690.
NMPDR	fig|283166.1.peg.60.
PATRIC	20543843. VBIBarHen29080_0082.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q6G552.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	BHEN283166:BH00690-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BARHE

Accession

Primary (citable) accession number: Q6G552

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program