Reviewed, UniProtKB/Swiss-Prot Q6G545 (AROA_BARHE)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BH00950

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm Probable HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325334

Sequences

	Sequence		Length	Mass (Da)
	Q6G545-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1B9D1F951BE1982D	FASTA	442	47,515
	10 20 30 40 50 60 MQKTIPMTAY KSTRLSGIIK IPGDKSISHR SLILGGLASG ETHIHGILES DDVFNTAAAM 70 80 90 100 110 120 QALGACIIKK DDLWIIRGTG NGCLLAAQKP LDFGNAGTGA RLVMGMVGPY HMKTTFIGDA 130 140 150 160 170 180 SLSKRPMARI LDPLQLMGVE IEATHGNYLP LTLYGPKMTN PICYRIPVAS AQVKSAILLA 190 200 210 220 230 240 GLNTAGTTTV IEPILTRDHT EKMLKAFGAK LEIEKNAEGT RFIHLNGHPH LTGQTIHIPG 250 260 270 280 290 300 DPSSAAFPIV AALLIEDSDI TIENVLINNS RMGLIETLWE MGAQIELLNQ RQTGGEDVAN 310 320 330 340 350 360 LRVKSSVLKG VTVPKERAPS MIDEYPALAV AAAFAEGKTV MLGIEELRVK ESDRLSVLAQ 370 380 390 400 410 420 GLKINHVDCE EGQDFLIVHG KGSAKGLGGG HVTTHLDHRI AMSFLIFGLV SEKPVTIDDK 430 440 RMIATSFPEF IPFIQQLGGK IS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF26911.1.
RefSeq	YP_032958.1.
3D structure databases
HSSP	HSSP built from PDB template 1RF6 based on UniProtKB Q9S400.
SMR	Q6G545. Positions 6-441.
ModBase	Search...
Genome annotation databases
GeneID	2866077.
GenomeReviews	Gene locus BH00950 in contig BX897699_GR.
KEGG	bhe:BH00950.
NMPDR	fig|283166.1.peg.86.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	NITIETS.
Enzyme and pathway databases
BioCyc	BHEN283166:BH00950-MONOMER.
BRENDA	2.5.1.19. 277357.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BARHE

Accession

Primary (citable) accession number: Q6G545

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)