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Q6G4W3

- TRMB_BARHE

UniProt

Q6G4W3 - TRMB_BARHE

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, BH02190
Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621S-adenosyl-L-methionine By similarity
Binding sitei87 – 871S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Active sitei138 – 1381 By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine By similarity
Binding sitei142 – 1421Substrate By similarity
Binding sitei174 – 1741Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBHEN283166:GIVZ-219-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:BH02190
    OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
    Taxonomic identifieri283166 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000421: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171297Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi283166.BH02190.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6G4W3.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 2154Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiYLTFIKK.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6G4W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDHNIRTGK AFFGRRKGKR LRNSQLVLIK KLFPTLDINL NNSVPLNLTS    50
    LFSRKVKEVR LEIGFGGGEH LLHEMKHFPQ TGFIGIEPFI NGMAKMLMSL 100
    EEHKQYQNQL RLYNDDATGL LDWLPNASLD GIDLFYPDPW PKKKHWKRRF 150
    INMKNLNRFA RVLKTGKKFR FASDIESYVN WTLYHCSNHH SFEWEAKNPK 200
    DWKTPYTLWS GTRYEAKALR EGRAPTYLTF IKK 233
    Length:233
    Mass (Da):27,515
    Last modified:July 19, 2004 - v1
    Checksum:i778154B3E04E820F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF27031.1.
    RefSeqiWP_011180170.1. NC_005956.1.
    YP_033072.1. NC_005956.1.

    Genome annotation databases

    EnsemblBacteriaiCAF27031; CAF27031; BH02190.
    GeneIDi2864622.
    KEGGibhe:BH02190.
    PATRICi20544183. VBIBarHen29080_0248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF27031.1 .
    RefSeqi WP_011180170.1. NC_005956.1.
    YP_033072.1. NC_005956.1.

    3D structure databases

    ProteinModelPortali Q6G4W3.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 283166.BH02190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF27031 ; CAF27031 ; BH02190 .
    GeneIDi 2864622.
    KEGGi bhe:BH02190.
    PATRICi 20544183. VBIBarHen29080_0248.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi YLTFIKK.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BHEN283166:GIVZ-219-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49882 / Houston 1.

    Entry informationi

    Entry nameiTRMB_BARHE
    AccessioniPrimary (citable) accession number: Q6G4W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 19, 2004
    Last modified: September 3, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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