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Q6G4W3

- TRMB_BARHE

UniProt

Q6G4W3 - TRMB_BARHE

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, BH02190
Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621S-adenosyl-L-methionine By similarity
Binding sitei87 – 871S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Active sitei138 – 1381 By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine By similarity
Binding sitei142 – 1421Substrate By similarity
Binding sitei174 – 1741Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-219-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:BH02190
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171297Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283166.BH02190.

Structurei

3D structure databases

ProteinModelPortaliQ6G4W3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 2154Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiYLTFIKK.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6G4W3-1 [UniParc]FASTAAdd to Basket

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MIDHNIRTGK AFFGRRKGKR LRNSQLVLIK KLFPTLDINL NNSVPLNLTS    50
LFSRKVKEVR LEIGFGGGEH LLHEMKHFPQ TGFIGIEPFI NGMAKMLMSL 100
EEHKQYQNQL RLYNDDATGL LDWLPNASLD GIDLFYPDPW PKKKHWKRRF 150
INMKNLNRFA RVLKTGKKFR FASDIESYVN WTLYHCSNHH SFEWEAKNPK 200
DWKTPYTLWS GTRYEAKALR EGRAPTYLTF IKK 233
Length:233
Mass (Da):27,515
Last modified:July 19, 2004 - v1
Checksum:i778154B3E04E820F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27031.1.
RefSeqiWP_011180170.1. NC_005956.1.
YP_033072.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF27031; CAF27031; BH02190.
GeneIDi2864622.
KEGGibhe:BH02190.
PATRICi20544183. VBIBarHen29080_0248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27031.1 .
RefSeqi WP_011180170.1. NC_005956.1.
YP_033072.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G4W3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH02190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF27031 ; CAF27031 ; BH02190 .
GeneIDi 2864622.
KEGGi bhe:BH02190.
PATRICi 20544183. VBIBarHen29080_0248.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi YLTFIKK.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BHEN283166:GIVZ-219-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiTRMB_BARHE
AccessioniPrimary (citable) accession number: Q6G4W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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