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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciBHEN283166:G1GJ7-282-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:BH02710
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063311 – 383L-lactate dehydrogenaseAdd BLAST383

Proteomic databases

PaxDbiQ6G4R2
PRIDEiQ6G4R2

Interactioni

Protein-protein interaction databases

STRINGi283166.BH02710

Structurei

3D structure databases

ProteinModelPortaliQ6G4R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 380FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST380

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMF Bacteria
COG1304 LUCA
HOGENOMiHOG000217464
KOiK00101
OMAiMQLYIYK
OrthoDBiPOG091H00L7

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G4R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISSTLDYR KAAKRRLPPF LFHYIDGGAY AEETMRRNYA DLQALALRQR
60 70 80 90 100
ILRGVGEVDL STKLFDQTLD LPIILAPVGL TGMYARRGEV QAARAAVAKG
110 120 130 140 150
IPFTLSSVSV CPIAEVQKAV GSAFWFQLYV LKDRGFMRDV LERSWASGVR
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGSYAGLR RILQAFIHPH WAWNVGIMGR
210 220 230 240 250
PHDLGNVSTY LQKKIALDDY IGWLGANFDP SIGWHDLQWI RDFWKGKMIL
260 270 280 290 300
KGILDPEDAR EAIQFGADGI VVSNHGGRQL DGVLSTVRAL PAIAEAVKSD
310 320 330 340 350
LTILVDSGVR SGLDVVRMIA QGADAVMIGR AFVYALAAAG EKGVAHLIDL
360 370 380
FANEMRVAMT LTGVRAIKEI TRESLASPDV FEQ
Length:383
Mass (Da):42,129
Last modified:July 19, 2004 - v1
Checksum:iCCEA4E2FEFB6AF1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF27083.1
RefSeqiWP_011180221.1, NZ_LRIJ01000002.1

Genome annotation databases

EnsemblBacteriaiCAF27083; CAF27083; BH02710
GeneIDi29620822
KEGGibhe:BH02710

Similar proteinsi

Entry informationi

Entry nameiLLDD_BARHE
AccessioniPrimary (citable) accession number: Q6G4R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health