Q6G4D4 (AROC_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BH04320

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Chorismate synthase HAMAP MF_00300		PRO_0000140555

Sequences

	Sequence		Length	Mass (Da)
	Q6G4D4 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: B07D28CE15EE88D4	FASTA	366	39,494
	10 20 30 40 50 60 MSHNTFGHLF RVTTWGESHG EALGCVIDGC PPGITFTLSD IQSYLNKRKP GQSKYTTQRR 70 80 90 100 110 120 ELDQVEILSG VIVQDDGITF VTTGTPISLL IRNMDQRSKD YSAIVHQYRP GHADYTYDVK 130 140 150 160 170 180 YGIRDFRGGG RASARETAAR VAAGAVARKI IPGVIVRGAV IAIGPHTINR NRWNWSEVDN 190 200 210 220 230 240 NPFFTPDAEM VQVFSDYIDK VHKNGSSVGA VVEIVAENIP AGLGAPIYAK LDQDIASLLM 250 260 270 280 290 300 SINAVKGVEI GDGFAAARLT GEENADEMRM GSDGKPLFLS NHAGGIVGGI SSGQPIIARF 310 320 330 340 350 360 AVKPTSSILI PRRSIDVDGN DVNVITKGRH DPCVGIRAVP VGEAMVACAL ADHYLRHRGQ VGCFKR

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27241.1.
RefSeq	YP_033270.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q6G4D4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2866079.
GenomeReviews	Gene locus BH04320 in contig BX897699_GR.
KEGG	bhe:BH04320.
NMPDR	fig|283166.1.peg.398.
PATRIC	20544639. VBIBarHen29080_0473.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q6G4D4.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BHEN283166:BH04320-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BARHE

Accession

Primary (citable) accession number: Q6G4D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program