Q6G4C4 (KHSE_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HSK
Short name=HK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BH04420

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Homoserine kinase HAMAP MF_00301		PRO_1000022575

Sequences

	Sequence		Length	Mass (Da)
	Q6G4C4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: C88064B9A3BC0813	FASTA	319	36,728
	10 20 30 40 50 60 MAVHTDIHPN DLKAFLTRYS IGSLLSYQGI VEGIENSNFM LYTTEGKFIL TLYEQRISKD 70 80 90 100 110 120 DLPFFCNLMQ HLGRRGVPCP QPVIQNNGMM IGELAGRPAA IITFLEGEWV RQSNIYHCCE 130 140 150 160 170 180 VGCSLAQLHL AAQDFSLSRR NTLSLVDWKC LWKRCQVRKD PLLREFGKKI DTELAFLEEN 190 200 210 220 230 240 WPSILPTGII HADLFNDNVF FLNDRLSGII DFYFACNDFW AYDLAICLNA WCFEHDHSYN 250 260 270 280 290 300 LIKARGLLES YQKIRPLVPL ELNAIVLLAR GAALRFLLTR LYDWFNTPPG SVVVKKDPWE 310 YWHKLCFFSN VGSLSELGF

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27251.1.
RefSeq	YP_033280.1.
3D structure databases
ProteinModelPortal	Q6G4C4.
SMR	Q6G4C4. Positions 5-319.
ModBase	Search...
Genome annotation databases
GeneID	2865220.
GenomeReviews	Gene locus BH04420 in contig BX897699_GR.
KEGG	bhe:BH04420.
NMPDR	fig|283166.1.peg.408.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ADLFRDN.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	BHEN283166:BH04420-MONOMER.
BRENDA	2.7.1.39. 277357.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_Kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BARHE

Accession

Primary (citable) accession number: Q6G4C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 19, 2004
Last modified:	August 10, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)