Reviewed,
UniProtKB/Swiss-Prot Q6G468 (DAPA_BARHE)
Last modified
February 9, 2010.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydrodipicolinate synthase Short name=DHDPS EC=4.2.1.52 | ||||
| Gene names |
| ||||
| Organism | Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 38323 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella |
Protein attributes
| Sequence length | 294 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418 |
| Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_00418 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00418. |
| Sequence similarities | Belongs to the DHDPS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | dihydrodipicolinate synthase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 294 | 294 | Dihydrodipicolinate synthase HAMAP MF_00418 | PRO_1000050166 | |||||
Regions | |||||||||
| Region | 48 – 49 | 2 | Pyruvate binding By similarity | ||||||
Sites | |||||||||
| Active site | 162 | 1 | Schiff-base intermediate with substrate By similarity | ||||||
| Binding site | 106 | 1 | Pyruvate By similarity | ||||||
| Site | 133 | 1 | Involved in proton transfer during cleavage By similarity | ||||||
Sequences
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References
| [1] | "The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX897699 Genomic DNA. Translation: CAF27308.1. |
| RefSeq | YP_033336.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2A6N based on UniProtKB P0A6L2. |
| SMR | Q6G468. Positions 1-288. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2864503. |
| GenomeReviews | Gene locus BH05000 in contig BX897699_GR. |
| KEGG | bhe:BH05000. |
| NMPDR | fig|283166.1.peg.464. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG358848. |
| OMA | IYNIPPR. |
| PhylomeDB | Q6G468. |
Enzyme and pathway databases | |
| BioCyc | BHEN283166:BH05000-MONOMER. |
| BRENDA | 4.2.1.52. 277357. |
Family and domain databases | |
| HAMAP | MF_00418. DapA. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR005263. DapA_synth. IPR002220. Dihydrodipicolinate_synth. IPR020625. Dihydrodipicolinate_synth_AS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR12128. DHDPS. 1 hit. |
| Pfam | PF00701. DHDPS. 1 hit. [Graphical view] |
| PRINTS | PR00146. DHPICSNTHASE. |
| TIGRFAMs | TIGR00674. dapA. 1 hit. |
| PROSITE | PS00665. DHDPS_1. False negative. PS00666. DHDPS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DAPA_BARHE | ||||||||
| Accession | Primary (citable) accession number: Q6G468 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


