Reviewed, UniProtKB/Swiss-Prot Q6G439 (KGUA_BARHE)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BH05390

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Guanylate kinase HAMAP MF_00328		PRO_0000170500
Regions
	Domain	19 – 197	179	Guanylate kinase-like
	Nucleotide binding	26 – 33	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G439-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 7E1DB17DD380479F	FASTA	222	25,925
	10 20 30 40 50 60 MVTFFENELS AKKRNQRRGF LFILSSPSGA GKSTLSRLLL KDGKLELSIS MTTRQKRPSE 70 80 90 100 110 120 VDGLHYHFIS KKEFKRKRDG NEFIEWAEVH GNYYGTLRES VENVLSTGRD MLFDIDYQGT 130 140 150 160 170 180 KQLQKKMPGD TVSVFILPPS MKELISRLYR RAEDSQDIIN LRLKNARTEM QHWRSYDYVI 190 200 210 220 INENLNQSVS LIKSIYLAET VKRERCFFLE PFINGLIAEK ID

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27347.1.
RefSeq	YP_033374.1.
3D structure databases
SMR	Q6G439. Positions 18-219.
ModBase	Search...
Genome annotation databases
GeneID	2865032.
GenomeReviews	Gene locus BH05390 in contig BX897699_GR.
KEGG	bhe:BH05390.
NMPDR	fig|283166.1.peg.502.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG671982.
OMA	EWAEFAG.
PhylomeDB	Q6G439.
Enzyme and pathway databases
BioCyc	BHEN283166:BH05390-MONOMER.
BRENDA	2.7.4.8. 277357.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BARHE

Accession

Primary (citable) accession number: Q6G439

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)