Q6G3W4 (Q6G3W4_BARHE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-a-disaccharide synthase EMBL CAF27437.1

Gene names

Name:	lpxB EMBL CAF27437.1
Ordered Locus Names:	BH06330

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6G3W4 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 76ABC9EBD3054E1E	FASTA	401	45,266
	10 20 30 40 50 60 MNKCFLKIAI VAGEESGDLL GADLISCLSQ QTGCKIDLIG VGGRHLKALG LKSFFDFQDI 70 80 90 100 110 120 ALIGLGTVLK KLPLLLIHIH NLSKFIAKEQ PDCLIIIDSP DFTHRVAKKV HVLAPSIPII 130 140 150 160 170 180 KYIAPTVWAW RPERAKAMRK FVDHVLAVFP FEKKIMQDLG GPPTTYVGHR LLTYPPLLTI 190 200 210 220 230 240 QSKKRHQSEK KHVFAKQTSS PTLVILPGSR NLEIRYLMPI FREAVEILIQ RIPHLHIILP 250 260 270 280 290 300 TLPHFVDEIR AFVQSWKNKV EILVDEDAKW HAFSKADVAL AALGTVSLEL ALAKIPMVLC 310 320 330 340 350 360 YKLDRFSKLF IFPKIMLWSA ALPNIISDKP IVPEYFNEFL RPGMLARQIE ELLYNPLLRQ 370 380 390 400 AQLDVFEMVE QKMKTEVPSG VIAAQTIVTL LKKRSGSLKF S

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27437.1.
RefSeq	YP_033462.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q6G3W4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2865599.
GenomeReviews	Gene locus BH06330 in contig BX897699_GR.
KEGG	bhe:BH06330.
NMPDR	fig|283166.1.peg.590.
PATRIC	20545083. VBIBarHen29080_0690.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	Q6G3W4.
ProtClustDB	PRK00025.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6G3W4_BARHE

Accession

Primary (citable) accession number: Q6G3W4

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)