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Q6G3V8

- SYE1_BARHE

UniProt

Q6G3V8 - SYE1_BARHE

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Protein
Glutamate--tRNA ligase 1
Gene
gltX1, BH06390
Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei241 – 2411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1 (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase 1
Short name:
GluRS 1
Gene namesi
Name:gltX1
Ordered Locus Names:BH06390
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Glutamate--tRNA ligase 1UniRule annotation
PRO_0000119510Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH06390.

Structurei

3D structure databases

ProteinModelPortaliQ6G3V8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 1911"HIGH" regionUniRule annotation
Add
BLAST
Motifi238 – 2425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252722.
KOiK01885.
OMAiAMGWEVP.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6G3V8-1 [UniParc]FASTAAdd to Basket

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MPVITRFAPS PTGFLHIGGA RTALFNWLYA KHTGGKMLLR IEDTDRERST    50
EAAVKAIIDG LHWMGLSYDG DPISQFERAE RHRQVAEQLV KDGKAYYCYA 100
SPEELAEIRE NARAEGRPPR YDGRWRERDI SKAPKDIKPV IRIKAPQDGE 150
TIVHDRVQGD VRFPNKDLDD FIILRSDGSP TYMHAVVVDD HDMGVTHIIR 200
GDDHLTNAAR QTIIFNAMGW DIPVMAHIPL IHGENGAKLS KRHGALGVAA 250
YRKMGYLPAA LRNYLVRLGW SHGDDELMSI EDMISWFDID DINKGAARFD 300
LKKLDAINGH YIRMSNNQDL FDAALHILKE IEGGLQIMER LDEQRRAQFL 350
KAIPNLKERS KTLCELIDNA SFIFTKRPLQ LDEKAQTLLD KNGLAILKVI 400
YLALKACPSW DVKSLDETLR SYAQTQDLKF GSIAQPLRAA LTGRLTSPGV 450
FDVLVLLGRD ESLNRINDQL VTTACSLHTN QCI 483
Length:483
Mass (Da):54,498
Last modified:July 19, 2004 - v1
Checksum:i80F1C9B91C12ABED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27443.1.
RefSeqiYP_033468.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF27443; CAF27443; BH06390.
GeneIDi2864753.
KEGGibhe:BH06390.
PATRICi20545095. VBIBarHen29080_0696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27443.1 .
RefSeqi YP_033468.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G3V8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 283166.BH06390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF27443 ; CAF27443 ; BH06390 .
GeneIDi 2864753.
KEGGi bhe:BH06390.
PATRICi 20545095. VBIBarHen29080_0696.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252722.
KOi K01885.
OMAi AMGWEVP.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci BHEN283166:GIVZ-638-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiSYE1_BARHE
AccessioniPrimary (citable) accession number: Q6G3V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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