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Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei252ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHEN283166:G1GJ7-668-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 2UniRule annotation
Short name:
GluRS 2UniRule annotation
Gene namesi
Name:gltX2UniRule annotation
Ordered Locus Names:BH06460
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195111 – 459Glutamate--tRNA ligase 2Add BLAST459

Proteomic databases

PaxDbiQ6G3V1
PRIDEiQ6G3V1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH06460

Structurei

3D structure databases

ProteinModelPortaliQ6G3V1
SMRiQ6G3V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi249 – 253"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G3V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVRFAPSP TGYIHIGNIR IALFNWLYAQ AHNGTFILRY DNTDVERSKQ
60 70 80 90 100
EYIDAIAVDL EWLGIQPDEI YYQSKRFNRY DEVAEILKQR GLLYPCYETA
110 120 130 140 150
EELDRRRKIQ LSRKLPPVYD RAALKLTPEK KREFETQGRK PHWRFLLPNF
160 170 180 190 200
ENDPLQKKRT EVCWNDAVKG KQTIDLASLS DPVLIREDGS YLYTLPSVVD
210 220 230 240 250
DIDMAITHII RGDDHITNTG AQIALFEALN AKLPTFGHIN LLTTLLGKGL
260 270 280 290 300
SKRNNDLSIH SLRADGFESI AVQCLAVLIG TSQNVHPYPN QAVLLEHFNL
310 320 330 340 350
QDTSRSVAKF DIADLLTLNS HFVHELTYEE VKKRLENLSI NGEKVECFWN
360 370 380 390 400
AIRSNINKVN DAVLWWKMLH DEQNFDTVAL EDRAFVRQSL NLLPEGTLNE
410 420 430 440 450
ESWKVWTVAL KEKTGRRGKA LFMPLRQALT GMDHGPEMGK ILQLLGREKV

IERLIIQGE
Length:459
Mass (Da):52,847
Last modified:July 19, 2004 - v1
Checksum:iCC9AB73BC04B3047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF27450.1
RefSeqiWP_011180570.1, NZ_LRIJ02000001.1

Genome annotation databases

EnsemblBacteriaiCAF27450; CAF27450; BH06460
GeneIDi29621145
KEGGibhe:BH06460

Similar proteinsi

Entry informationi

Entry nameiSYE2_BARHE
AccessioniPrimary (citable) accession number: Q6G3V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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