Reviewed, UniProtKB/Swiss-Prot Q6G3F3 (PYRB_BARHE)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BH08200

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113101

Sequences

	Sequence		Length	Mass (Da)
	Q6G3F3-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 7338C1CBBC35FDAB	FASTA	321	34,848
	10 20 30 40 50 60 MTQNTFFSLF PHQHLLGIKD LSVQDLTILL DRANANVPFL KKSDKKQSIL HGRTQINLFF 70 80 90 100 110 120 EASTRTQSSF ELAGKRLGAD VMSMAIGNSS VKKGETLVDT ATTLNAMKPD ILVIRHSCAG 130 140 150 160 170 180 AAALLAQKVD CCVINAGDGA HEHPTQALLD ALTIQRTKGR IEGLTVAICG DILHSRVARS 190 200 210 220 230 240 NILSLNALGA CVRVIAPSTL LPASIADMSV EVYNTMKEGL KGADVIMMLR LQQERMTGSF 250 260 270 280 290 300 IPSIREYFHY FGLHKENLAY AKSDCIILHP GPINRGVEIA SDIADGPQSM IHTQVEMGIA 310 320 VRMAVMEALL DSRLKASGEK K

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27619.1.
RefSeq	YP_033626.1.
3D structure databases
SMR	Q6G3F3. Positions 9-313.
ModBase	Search...
Genome annotation databases
GeneID	2864779.
GenomeReviews	Gene locus BH08200 in contig BX897699_GR.
KEGG	bhe:BH08200.
NMPDR	fig|283166.1.peg.754.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	VMMLRVQ.
PhylomeDB	Q6G3F3.
Enzyme and pathway databases
BioCyc	BHEN283166:BH08200-MONOMER.
BRENDA	2.1.3.2. 277357.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BARHE

Accession

Primary (citable) accession number: Q6G3F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)