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Q6G3F3 (PYRB_BARHE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase

EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:BH08200
OrganismBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]
Taxonomic identifier283166 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Aspartate carbamoyltransferase HAMAP MF_00001
PRO_0000113101

Sequences

Sequence LengthMass (Da)Tools
Q6G3F3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 7338C1CBBC35FDAB

FASTA32134,848
        10         20         30         40         50         60 
MTQNTFFSLF PHQHLLGIKD LSVQDLTILL DRANANVPFL KKSDKKQSIL HGRTQINLFF 

        70         80         90        100        110        120 
EASTRTQSSF ELAGKRLGAD VMSMAIGNSS VKKGETLVDT ATTLNAMKPD ILVIRHSCAG 

       130        140        150        160        170        180 
AAALLAQKVD CCVINAGDGA HEHPTQALLD ALTIQRTKGR IEGLTVAICG DILHSRVARS 

       190        200        210        220        230        240 
NILSLNALGA CVRVIAPSTL LPASIADMSV EVYNTMKEGL KGADVIMMLR LQQERMTGSF 

       250        260        270        280        290        300 
IPSIREYFHY FGLHKENLAY AKSDCIILHP GPINRGVEIA SDIADGPQSM IHTQVEMGIA 

       310        320 
VRMAVMEALL DSRLKASGEK K 

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX897699 Genomic DNA. Translation: CAF27619.1.
RefSeqYP_033626.1. NC_005956.1.

3D structure databases

ProteinModelPortalQ6G3F3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2864779.
GenomeReviewsGene locus BH08200 in contig BX897699_GR.
KEGGbhe:BH08200.
NMPDRfig|283166.1.peg.754.
PATRIC20545455. VBIBarHen29080_0870.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMALQRERMS.
PhylomeDBQ6G3F3.
ProtClustDBPRK00856.

Enzyme and pathway databases

BioCycBHEN283166:BH08200-MONOMER.

Family and domain databases

HAMAPMF_00001. Asp_carb_tr.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002082. Asp_carbamoyltransf_euk.
[Graphical view]
KOK00609.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00670. Asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_BARHE
AccessionPrimary (citable) accession number: Q6G3F3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families