Reviewed, UniProtKB/Swiss-Prot Q6G330 (SYD_BARHE)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BH09790

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00044
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_0000110831

Sequences

	Sequence		Length	Mass (Da)
	Q6G330-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: BEFD90DE89257CED	FASTA	596	67,626
	10 20 30 40 50 60 MHRYRSHHCA ALRKCDVGIK ARLSGWVHRV RDHGGILFVD LRDHFGITQI VADPASPAFK 70 80 90 100 110 120 IIEKVRSEWV IRVDGEVRAR SDEVINTSLP TGEIEIFAKE VEILSKSDEL PLPVFGEPDY 130 140 150 160 170 180 PEDIRLKYRF LDLRRETMHR NIMRRTEIIA AIRRSMQENG FTEFTTPLLT ASSPEGARDF 190 200 210 220 230 240 LVPSRIHQGK FYALPQAPQQ YKQLLMMSGF DRYFQIAPCF RDEDPRADRL PGEFYQLDVE 250 260 270 280 290 300 MSFVEQEDVL VTMEPIMRSL FEEFADGKPV TQSFPRLSYE EAMRKYGSDK PDLRNPIIME 310 320 330 340 350 360 DVSQHFYDSG FKVFAQILAN DENARVWAIP AKTGGSRAFC DRMNGWAQSE GQPGLGYIFW 370 380 390 400 410 420 REEQGKFEGA GPIAKNIGEQ RTEALRMQLG LENGDACFFV AGDPKKFLPF AGAARTRVGE 430 440 450 460 470 480 ELDLVDRDCF SLAWIVDFPF FEWNEEEKKL DFAHNPFSMP QGGKDALECQ DPLTLKAFQY 490 500 510 520 530 540 DLVCNGYEIA SGGIRNHSPE MMLKVFNLAG LSKEVVEDRF GGLYRAFHYG APPHGGMAAG 550 560 570 580 590 VDRIIMLLQG VKNLREVALF PMNQQALDLL MSAPSDVSPV QLRDLGIRIA PAAKND

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF27772.1.
RefSeq	YP_033770.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866084.
GenomeReviews	Gene locus BH09790 in contig BX897699_GR.
KEGG	bhe:BH09790.
NMPDR	fig|283166.1.peg.898.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G330.
OMA	Q6G330. YQLDVEM.
Enzyme and pathway databases
BioCyc	BHEN283166:BH09790-MON.
BRENDA	6.1.1.12. 277357.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BARHE

Accession

Primary (citable) accession number: Q6G330

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)