Q6G330 (SYD_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate--tRNA ligase
EC=6.1.1.12

Alternative name(s):
Aspartyl-tRNA synthetase
Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BH09790

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044_B
Subunit structure	Homodimer By similarity. HAMAP MF_00044_B
Subcellular location	Cytoplasm HAMAP MF_00044_B.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA aminoacylation for protein translation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Aspartate--tRNA ligase HAMAP MF_00044_B		PRO_0000110831

Sequences

	Sequence		Length	Mass (Da)
	Q6G330 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: BEFD90DE89257CED	FASTA	596	67,626
	10 20 30 40 50 60 MHRYRSHHCA ALRKCDVGIK ARLSGWVHRV RDHGGILFVD LRDHFGITQI VADPASPAFK 70 80 90 100 110 120 IIEKVRSEWV IRVDGEVRAR SDEVINTSLP TGEIEIFAKE VEILSKSDEL PLPVFGEPDY 130 140 150 160 170 180 PEDIRLKYRF LDLRRETMHR NIMRRTEIIA AIRRSMQENG FTEFTTPLLT ASSPEGARDF 190 200 210 220 230 240 LVPSRIHQGK FYALPQAPQQ YKQLLMMSGF DRYFQIAPCF RDEDPRADRL PGEFYQLDVE 250 260 270 280 290 300 MSFVEQEDVL VTMEPIMRSL FEEFADGKPV TQSFPRLSYE EAMRKYGSDK PDLRNPIIME 310 320 330 340 350 360 DVSQHFYDSG FKVFAQILAN DENARVWAIP AKTGGSRAFC DRMNGWAQSE GQPGLGYIFW 370 380 390 400 410 420 REEQGKFEGA GPIAKNIGEQ RTEALRMQLG LENGDACFFV AGDPKKFLPF AGAARTRVGE 430 440 450 460 470 480 ELDLVDRDCF SLAWIVDFPF FEWNEEEKKL DFAHNPFSMP QGGKDALECQ DPLTLKAFQY 490 500 510 520 530 540 DLVCNGYEIA SGGIRNHSPE MMLKVFNLAG LSKEVVEDRF GGLYRAFHYG APPHGGMAAG 550 560 570 580 590 VDRIIMLLQG VKNLREVALF PMNQQALDLL MSAPSDVSPV QLRDLGIRIA PAAKND

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF27772.1.
RefSeq	YP_033770.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q6G330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2866084.
GenomeReviews	Gene locus BH09790 in contig BX897699_GR.
KEGG	bhe:BH09790.
NMPDR	fig|283166.1.peg.898.
PATRIC	20545779. VBIBarHen29080_1026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG396032.
OMA	YQLDVEM.
PhylomeDB	Q6G330.
ProtClustDB	PRK00476.
Enzyme and pathway databases
BioCyc	BHEN283166:BH09790-MONOMER.
Family and domain databases
HAMAP	MF_00044_B. Asp_tRNA_synth_B. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:3.30.1360.30. GAD_dom. 1 hit. G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01876.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF55261. SSF55261. 1 hit.
TIGRFAMs	TIGR00459. AspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BARHE

Accession

Primary (citable) accession number: Q6G330

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program