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Q6G322

- GLMS_BARHE

UniProt

Q6G322 - GLMS_BARHE

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, BH09920
Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei602 – 6021For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-989-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:BH09920
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135302Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH09920.

Structurei

3D structure databases

ProteinModelPortaliQ6G322.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2Add
BLAST
Domaini277 – 422146SIS 1Add
BLAST
Domaini455 – 597143SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6G322-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIIGILGK RCVTSSLVES LKRLEYRGYD SSGIATVHNG RLYRIRAEGK    50
LVHLEEKLQK TPLKGNLGIG HTRWATHGVA VERNAHPHVT ERLAIVHNGI 100
IENFVELQKE LIEDGYTFET ETDTEVIAHL ITRALKSGLS PQEAIRTSWK 150
RLQGAFAIVV IFEGEDNLMI AARSGPPLAI GYGKDEFFVG SDAIALAPFV 200
DSISYMEDGD WAVLTREDIT IYDVDNQPVK RPLTPLFEGA LLASKGNHRH 250
FMHKEMFEQP EVISHNLAHY LDLGNYTVRS FQKLIDWKKI NRILFASCGT 300
AYYSTLVARY WFESFAALSV DNDVASEFRY REPPINSDVL SVFVSQSGET 350
ADTLASLRYC REYGVKTATI VNVEQSTMAR EADFVLPTRA GPEIGVASTK 400
AFTCQLATLA AMALDAAKQR GFLAEQAEHQ FVQQLAEVPR ILNEVLKLDN 450
KIEQICRNLV NVKGVLYLGR GTSYPIALEG ALKLKELSYI HAEGYAAGEL 500
KHGPIALVDE AIPVIVVAPY DRWFEKTCSN MQEVAARNGR IILITDKKGA 550
EAVHLDILST IVLPNIPEFI APIIYALPIQ LIAYHTAVLL GTDVDQPRNL 600
AKSVTVE 607
Length:607
Mass (Da):67,361
Last modified:January 23, 2007 - v3
Checksum:i07C5B4862CE25BE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27784.1.
RefSeqiWP_011180858.1. NC_005956.1.
YP_033778.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF27784; CAF27784; BH09920.
GeneIDi2864740.
KEGGibhe:BH09920.
PATRICi20545809. VBIBarHen29080_1041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897699 Genomic DNA. Translation: CAF27784.1 .
RefSeqi WP_011180858.1. NC_005956.1.
YP_033778.1. NC_005956.1.

3D structure databases

ProteinModelPortali Q6G322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283166.BH09920.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF27784 ; CAF27784 ; BH09920 .
GeneIDi 2864740.
KEGGi bhe:BH09920.
PATRICi 20545809. VBIBarHen29080_1041.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BHEN283166:GIVZ-989-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiGLMS_BARHE
AccessioniPrimary (citable) accession number: Q6G322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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