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Q6G322

- GLMS_BARHE

UniProt

Q6G322 - GLMS_BARHE

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei602 – 6021For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciBHEN283166:GIVZ-989-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:BH09920
    OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
    Taxonomic identifieri283166 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000421: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135302Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi283166.BH09920.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6G322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini277 – 422146SIS 1UniRule annotationAdd
    BLAST
    Domaini455 – 597143SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6G322-1 [UniParc]FASTAAdd to Basket

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    MCGIIGILGK RCVTSSLVES LKRLEYRGYD SSGIATVHNG RLYRIRAEGK    50
    LVHLEEKLQK TPLKGNLGIG HTRWATHGVA VERNAHPHVT ERLAIVHNGI 100
    IENFVELQKE LIEDGYTFET ETDTEVIAHL ITRALKSGLS PQEAIRTSWK 150
    RLQGAFAIVV IFEGEDNLMI AARSGPPLAI GYGKDEFFVG SDAIALAPFV 200
    DSISYMEDGD WAVLTREDIT IYDVDNQPVK RPLTPLFEGA LLASKGNHRH 250
    FMHKEMFEQP EVISHNLAHY LDLGNYTVRS FQKLIDWKKI NRILFASCGT 300
    AYYSTLVARY WFESFAALSV DNDVASEFRY REPPINSDVL SVFVSQSGET 350
    ADTLASLRYC REYGVKTATI VNVEQSTMAR EADFVLPTRA GPEIGVASTK 400
    AFTCQLATLA AMALDAAKQR GFLAEQAEHQ FVQQLAEVPR ILNEVLKLDN 450
    KIEQICRNLV NVKGVLYLGR GTSYPIALEG ALKLKELSYI HAEGYAAGEL 500
    KHGPIALVDE AIPVIVVAPY DRWFEKTCSN MQEVAARNGR IILITDKKGA 550
    EAVHLDILST IVLPNIPEFI APIIYALPIQ LIAYHTAVLL GTDVDQPRNL 600
    AKSVTVE 607
    Length:607
    Mass (Da):67,361
    Last modified:January 23, 2007 - v3
    Checksum:i07C5B4862CE25BE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF27784.1.
    RefSeqiWP_011180858.1. NC_005956.1.
    YP_033778.1. NC_005956.1.

    Genome annotation databases

    EnsemblBacteriaiCAF27784; CAF27784; BH09920.
    GeneIDi2864740.
    KEGGibhe:BH09920.
    PATRICi20545809. VBIBarHen29080_1041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF27784.1 .
    RefSeqi WP_011180858.1. NC_005956.1.
    YP_033778.1. NC_005956.1.

    3D structure databases

    ProteinModelPortali Q6G322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283166.BH09920.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF27784 ; CAF27784 ; BH09920 .
    GeneIDi 2864740.
    KEGGi bhe:BH09920.
    PATRICi 20545809. VBIBarHen29080_1041.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci BHEN283166:GIVZ-989-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49882 / Houston 1.

    Entry informationi

    Entry nameiGLMS_BARHE
    AccessioniPrimary (citable) accession number: Q6G322
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 72 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3