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Q6G316 (SYR_BARHE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:BH09980
OrganismBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]
Taxonomic identifier283166 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000241988

Regions

Motif131 – 14111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q6G316 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 0A069C7C8C5846BB

FASTA58566,328
        10         20         30         40         50         60 
MNVFKNFEKK IKKSLESSDI KGKNGEDLDL SKITVDPPRD SSHGHLSTNA AMVLAKSTGL 

        70         80         90        100        110        120 
NPRALAEKII ELLKNDPSVE SINVAGPGFI NIKLTKPFWQ DLIKSMLEKG ISYGRIPMGQ 

       130        140        150        160        170        180 
GKRINVEYVS ANPTGPMHVG HCRGAVVGDV LSNLLQFVGY NITKEYYIND AGKQIEVLAH 

       190        200        210        220        230        240 
SVLLRYREAL GQKINEIPEG LYPGEYLIPL GQSLAQEFGD KLLTIDKEEA LSIVKERAIH 

       250        260        270        280        290        300 
EMMSMIRKDL AALNIYHDIF FSERMLYADN ARAIRNTIND LTLKGYIYKG KLPPPKGQNT 

       310        320        330        340        350        360 
EDWEPCEQTL FRSTDVGDDQ DRVLIKSDGS YTYFAADVAY FRDKFNRHFD EMIYILGADH 

       370        380        390        400        410        420 
AGYVKRLEAM AKAISNDKAK LSVFLCQLVK LFRNGHPVRM SKRAGSFVTL RDVVEEVGSD 

       430        440        450        460        470        480 
PVRFMMLYRK CEAPLDFDFA KVTEQSKDNP IFYVQYASAR CHSVFRQAQE TLCIENISND 

       490        500        510        520        530        540 
KIIEHLNRLT DDNEIFLIRK LSEYPRIIEQ AVVHKEPHRL AFYLYDLASS FHTHWNKGSD 

       550        560        570        580 
NLNLRFIQPD DRNLSFARLG LIQAIMNILS SGLAIVGIKA ATEMR 

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX897699 Genomic DNA. Translation: CAF27790.1.
RefSeqYP_033784.1. NC_005956.1.

3D structure databases

ProteinModelPortalQ6G316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING283166.BH09980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF27790; CAF27790; BH09980.
GeneID2866076.
KEGGbhe:BH09980.
PATRIC20545821. VBIBarHen29080_1047.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAIRNTIND.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycBHEN283166:GIVZ-995-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_BARHE
AccessionPrimary (citable) accession number: Q6G316
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries